Mouse Anti-RGS20 Recombinant Antibody (CBCNR-453) (CBMAB-R2452-CN)

Name: Mouse Anti-RGS20 Recombinant Antibody (CBCNR-453)
SKU: CBMAB-R2452-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-453

Application

WB, ELISA

Specificity

Mouse, Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

Regulator Of G Protein Signaling 20

Introduction

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Entrez Gene ID

Human	8601
Mouse	58175

UniProt ID

Human	O76081
Mouse	Q9QZB1

Alternative Names

Regulator Of G Protein Signaling 20; Regulator Of Gz-Selective Protein Signaling 1; Gz-Selective GTPase-Activating Protein; Regulator Of G-Protein Signalling 20; Regulator Of G-Protein Signaling 20; Regulator Of G-Protein Signaling Z1;

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Biological Process

Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane
Nucleus
Cytoplasm
Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.

PTM

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).
N- and O-glycosylated in synapsomal membranes.
Serine phosphorylated in synapsomal membranes.
Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

RGS20 Matched Antibody Pair (989) (CAT#: APMAB-989LY)

Related Products

RGS20 Matched Antibody Pair (989) (CAT#: APMAB-989LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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