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Mouse Anti-RGS20 Recombinant Antibody (CBCNR-453) (CBMAB-R2452-CN)

This product is a Mouse antibody that recognizes RGS20. The antibody CBCNR-453 can be used for immunoassay techniques such as: WB, ELISA.
See all RGS20 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
CBCNR-453
Antibody Isotype
IgG2a
Application
WB, ELISA

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
Regulator Of G Protein Signaling 20
Introduction
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Entrez Gene ID
Human8601
Mouse58175
UniProt ID
HumanO76081
MouseQ9QZB1
Alternative Names
Regulator Of G Protein Signaling 20; Regulator Of Gz-Selective Protein Signaling 1; Gz-Selective GTPase-Activating Protein; Regulator Of G-Protein Signalling 20; Regulator Of G-Protein Signaling 20; Regulator Of G-Protein Signaling Z1;
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
Biological Process
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Nucleus
Cytoplasm
Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.
PTM
Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).
N- and O-glycosylated in synapsomal membranes.
Serine phosphorylated in synapsomal membranes.
Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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