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Mouse Anti-SCUBE3 Recombinant Antibody (1D6) (CBMAB-A7939-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SCUBE3 (AAH52263.2, 29 a.a. ~ 147 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
signal peptide, CUB domain, EGF-like 3
Entrez Gene ID
222663
UniProt ID
Q8IX30
Alternative Names
CEGF3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743
Function
Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (PubMed:33308444).
It is required for ligand-induced recruitment of BMP receptors to lipid rafts (By similarity).
Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Biological Process
Biological Process positive regulation of BMP signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Cell surface
Involvement in disease
Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2 (SSFSC2):
An autosomal recessive disorder characterized by reduced growth, skeletal abnormalities, a distinctive craniofacial appearance, and dental anomalies. Cardiac anomalies have been reported in some patients.
PTM
N-glycosylated.
Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2. This reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP9.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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