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Mouse Anti-SFTPA1 Recombinant Antibody (CBXS-0313) (CBMAB-S3288-CQ)

This product is a mouse antibody that recognizes SFTPA1. The antibody CBXS-0313 can be used for immunoassay techniques such as: ELISA.
See all SFTPA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0313
Antibody Isotype
IgG3
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Surfactant Protein A1
Introduction
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
653509
UniProt ID
Q8IWL2
Alternative Names
Surfactant Protein A1; 35 KDa Pulmonary Surfactant-Associated Protein; Surfactant, Pulmonary-Associated Protein A1A; Alveolar Proteinosis Protein; Collectin-4; SFTPA1B; COLEC4; SFTP1; PSP-A; SP-A1; PSAP; PSPA; SP-A; Surfactant, Pulmonary-Associated Protein A1B; Surfactant, Pulmonary-Associated Protein A1; Pulmonary Surfactant-Associated Protein A1; Surfactant Protein A1 Variant ABD 6A2; Surfactant Protein A1 Variant ABD 6A3; Surfactant Protein A1 Variant ABD 6A4;
Function
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity).
(Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928).
Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169).3 Publications
(Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen (PubMed:15845487, PubMed:25139904).
When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen (PubMed:25139904).
Biological Process
Biological Process opsonizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process respiratory gaseous exchange by respiratory systemIEA:UniProtKB-KW
Cellular Location
Secreted
Secreted, extracellular space, extracellular matrix
Secreted, extracellular space, surface film
Involvement in disease
Interstitial lung disease 1 (ILD1):
A form of interstitial lung disease, a heterogeneous group of diseases affecting the distal part of the lung and characterized by a progressive remodeling of the alveolar interstitium. The disease spectrum ranges from idiopathic interstitial pneumonia or pneumonitis to idiopathic pulmonary fibrosis, that is associated with an increased risk of developing lung cancer. Clinical features of interstitial lung disease include dyspnea, clubbing of the fingers, and restrictive lung capacity. ILD1 inheritance can be autosomal dominant with incomplete penetrance, and autosomal recessive.
Respiratory distress syndrome in premature infants (RDS):
A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
PTM
N-acetylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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