SFTPA1
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Full Name
Surfactant Protein A1
Function
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity).
(Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928).
Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169).3 Publications
(Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen (PubMed:15845487, PubMed:25139904).
When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen (PubMed:25139904).
(Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928).
Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169).3 Publications
(Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen (PubMed:15845487, PubMed:25139904).
When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen (PubMed:25139904).
Biological Process
Biological Process opsonizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process respiratory gaseous exchange by respiratory systemIEA:UniProtKB-KW
Biological Process respiratory gaseous exchange by respiratory systemIEA:UniProtKB-KW
Cellular Location
Secreted
Secreted, extracellular space, extracellular matrix
Secreted, extracellular space, surface film
Secreted, extracellular space, extracellular matrix
Secreted, extracellular space, surface film
Involvement in disease
Interstitial lung disease 1 (ILD1):
A form of interstitial lung disease, a heterogeneous group of diseases affecting the distal part of the lung and characterized by a progressive remodeling of the alveolar interstitium. The disease spectrum ranges from idiopathic interstitial pneumonia or pneumonitis to idiopathic pulmonary fibrosis, that is associated with an increased risk of developing lung cancer. Clinical features of interstitial lung disease include dyspnea, clubbing of the fingers, and restrictive lung capacity. ILD1 inheritance can be autosomal dominant with incomplete penetrance, and autosomal recessive.
Respiratory distress syndrome in premature infants (RDS):
A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
A form of interstitial lung disease, a heterogeneous group of diseases affecting the distal part of the lung and characterized by a progressive remodeling of the alveolar interstitium. The disease spectrum ranges from idiopathic interstitial pneumonia or pneumonitis to idiopathic pulmonary fibrosis, that is associated with an increased risk of developing lung cancer. Clinical features of interstitial lung disease include dyspnea, clubbing of the fingers, and restrictive lung capacity. ILD1 inheritance can be autosomal dominant with incomplete penetrance, and autosomal recessive.
Respiratory distress syndrome in premature infants (RDS):
A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
PTM
N-acetylated.
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Anti-SFTPA1 antibodies
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CompareTarget: SFTPA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F10
Application*: ELISA, WB, IHC
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4D6
Application*: WB, E
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C4
Application*: WB, E
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H2
Application*: WB, E
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G8
Application*: WB, E
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E3
Application*: WB, E
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P836
Application*: WB, IC, P, C, E
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P835
Application*: WB, IC, P, C, E
Target: SFTPA1
Host: Mouse
Specificity: Human
Clone: CBXS-3180
Application*: E, IF, WB
Target: SFTPA1
Host: Mouse
Specificity: Human
Clone: CBXS-3065
Application*: E, WB
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXS-0313
Application*: E
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXS-0311
Application*: E, WB
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0310
Application*: E, P, WB
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4693
Application*: WB, P
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4191
Application*: E, WB
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-5824
Application*: E
Target: SFTPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-5223
Application*: WB, E, IH, P
Target: SFTPA1
Specificity: Human
Target: SFTPA1
Specificity: Human
Target: SFTPA1
Specificity: Human
Target: SFTPA1
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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