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Mouse Anti-SFTPB Recombinant Antibody (CBXS-0316) (CBMAB-S3291-CQ)

This product is a mouse antibody that recognizes SFTPB. The antibody CBXS-0316 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all SFTPB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0316
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Surfactant Associated Protein B
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Surfactant Protein B
Introduction
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
Entrez Gene ID
6439
UniProt ID
P07988
Alternative Names
Surfactant Protein B; Pulmonary Surfactant-Associated Proteolipid SPL(Phe); 18 KDa Pulmonary-Surfactant Protein; KDa Protein; SFTP3; SP-B;
Function
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Biological Process
Biological Process animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process respiratory gaseous exchange by respiratory systemManual Assertion Based On ExperimentTAS:ProtInc
Biological Process sphingolipid metabolic processIEA:InterPro
Cellular Location
Secreted, extracellular space, surface film
Involvement in disease
Pulmonary surfactant metabolism dysfunction 1 (SMDP1):
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Respiratory distress syndrome in premature infants (RDS):
A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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