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Mouse Anti-TOPORS Recombinant Antibody (1A5) (CBMAB-A9433-LY)

The product is antibody recognizes TOPORS. The antibody 1A5 immunoassay techniques such as: WB, ELISA.
See all TOPORS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TOPORS (NP_005793, 98 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
topoisomerase I binding, arginine/serine-rich
Entrez Gene ID
10210
UniProt ID
Q9NS56
Alternative Names
LUN; P53BP3; RP31; TP53BPL
Function
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Biological Process
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process DNA-templated transcription Source:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage Source:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source:Ensembl
Biological Process maintenance of protein location in nucleus Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic process Source:BHF-UCLBy Similarity
Biological Process photoreceptor cell outer segment organization Source:BHF-UCLBy Similarity
Biological Process positive regulation of DNA-templated transcription Source:Ensembl
Biological Process positive regulation of ubiquitin-protein transferase activity Source:BHF-UCL1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein K48-linked ubiquitination Source:BHF-UCL1 Publication
Biological Process protein localization to nucleus Source:UniProtKB1 Publication
Biological Process protein monoubiquitination Source:BHF-UCL1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL1 Publication
Biological Process protein sumoylation Source:UniProtKB1 Publication
Biological Process regulation of cell population proliferation Source:Ensembl
Biological Process retina layer formation Source:BHF-UCLBy Similarity
Biological Process retinal cone cell development Source:BHF-UCLBy Similarity
Biological Process retinal rod cell development Source:BHF-UCLBy Similarity
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Nucleus
Nucleus, PML body
Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
Involvement in disease
Retinitis pigmentosa 31 (RP31):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
PTM
Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation.
Sumoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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