Mouse Anti-TPO Recombinant Antibody (CBYJT-4371) (CBMAB-T3860-YJ)

Name: Mouse Anti-TPO Recombinant Antibody (CBYJT-4371)
SKU: CBMAB-T3860-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4371

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa672-779 from human TPO (NP_000538) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 672-779

More Infomation

Target

Full Name

Thyroid peroxidase

Introduction

TPO is a membrane-bound glycoprotein. TPO acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in TPO are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.

Entrez Gene ID

7173

UniProt ID

P07202

Alternative Names

Thyroid Peroxidase; EC 1.11.1.8; Thyroid Microsomal Antigen; Thyroperoxidase; EC 1.11.1; TDH2A; MSA; TPX

Function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

Biological Process

Biological Process embryonic hemopoiesis Source:DFLAT1 Publication
Biological Process hormone biosynthetic process Source:UniProtKB-KW
Biological Process hydrogen peroxide catabolic process Source:UniProtKB-KW
Biological Process response to oxidative stress Source:InterPro
Biological Process thyroid hormone generation Source:Reactome

Cellular Location

Membrane
Isoform 3
Cell surface

Involvement in disease

Thyroid dyshormonogenesis 2A (TDH2A):
A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.

Topology

Extracellular: 19-846
Helical: 847-871
Cytoplasmic: 872-933

PTM

Glycosylated.
Heme is covalently bound through a H2O2-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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