TPO

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
Full Name
Thyroid peroxidase
Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.
Biological Process
Biological Process embryonic hemopoiesis Source:DFLAT1 Publication
Biological Process hormone biosynthetic process Source:UniProtKB-KW
Biological Process hydrogen peroxide catabolic process Source:UniProtKB-KW
Biological Process response to oxidative stress Source:InterPro
Biological Process thyroid hormone generation Source:Reactome
Cellular Location
Membrane
Isoform 3
Cell surface
Involvement in disease
Thyroid dyshormonogenesis 2A (TDH2A):
A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
Topology
Extracellular: 19-846
Helical: 847-871
Cytoplasmic: 872-933
PTM
Glycosylated.
Heme is covalently bound through a H2O2-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.
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Anti-TPO antibodies

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Mouse Anti-TPO Recombinant Antibody (CBYJT-4368) (CBMAB-T3857-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4368
Application*: E, WB
Datasheet SDS

Rabbit Anti-TPO Recombinant Antibody (RM368) (CBMAB-BR475LY)

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Target: TPO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM368
Application*: IHC, WB
Datasheet SDS

Mouse Anti-TPO Recombinant Antibody (2A11) (CBMAB-A9460-LY)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2A11
Application*: WB, E
Datasheet SDS

Mouse Anti-Tpo Recombinant Antibody (CBYJT-4378) (CBMAB-T3871-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYJT-4378
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-Tpo Recombinant Antibody (CBYJT-4377) (CBMAB-T3870-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYJT-4377
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-Tpo Recombinant Antibody (CBYJT-4376) (CBMAB-T3869-YJ)

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Target: Tpo
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-4376
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TPO Recombinant Antibody (CBYJT-4375) (CBMAB-T3868-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4375
Application*: IO, SE
Datasheet SDS

Mouse Anti-TPO Recombinant Antibody (CBYJT-4374) (CBMAB-T3867-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4374
Application*: WB, IO, SE
Datasheet SDS

Mouse Anti-TPO Recombinant Antibody (CBYJT-4373) (CBMAB-T3866-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4373
Application*: WB, E, IO, SE
Datasheet SDS

Mouse Anti-TPO Recombinant Antibody (CBYJT-4372) (CBMAB-T3865-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4372
Application*: P, WB
Datasheet SDS

Mouse Anti-TPO Recombinant Antibody (CBYJT-4371) (CBMAB-T3860-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-4371
Application*: E, WB
Datasheet SDS

Mouse Anti-TPO Recombinant Antibody (CBYJT-4370) (CBMAB-T3859-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4370
Application*: E, WB
Datasheet SDS

Mouse Anti-TPO Recombinant Antibody (CBYJT-4369) (CBMAB-T3858-YJ)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4369
Application*: E, WB
Datasheet SDS

Mouse Anti-TPO Monoclonal Antibody (MoAb47) (CBMAB-1641-YC)

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Target: TPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MoAb47
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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