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Mouse Anti-UBE2B Monoclonal Antibody (1C7) (CBMAB-0281-LY)

This product is mouse monoclonal antibody recognizes UBE2B of human. The antibody 1C7 immunoassay techniques such as: MA, IP.
Host Species
Mouse
Application
IP, MA
Immunogen
Recombinant peptide (Full Length)
Antibody Isotype
IgG2b
Specificity
Human
Clone
1C7
Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
Alternative Name
HHR6B; RAD6B; UBC2
Entrez Gene ID
UniProt ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0281-LY
Conjugates
Size
Price $
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Second antibody and isotype control