Mouse Anti-UBE2B Monoclonal Antibody (1C7) (CBMAB-0281-LY)

UBE2B

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination.

HHR6B; RAD6B; UBC2

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

Biological Process apoptotic process Source:Ensembl
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process chiasma assembly Source:Ensembl
Biological Process DNA repair Source:UniProtKB1 Publication
Biological Process ectopic germ cell programmed cell death Source:Ensembl
Biological Process histone H2A ubiquitination Source:UniProtKB1 Publication
Biological Process histone lysine demethylation Source:Ensembl
Biological Process histone ubiquitination Source:GO_Central1 Publication
Biological Process in utero embryonic development Source:Ensembl
Biological Process meiotic telomere clustering Source:Ensembl
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process negative regulation of cAMP-mediated signaling Source:UniProtKB1 Publication
Biological Process negative regulation of developmental process Source:Ensembl
Biological Process negative regulation of post-translational protein modification Source:Ensembl
Biological Process negative regulation of reproductive process Source:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathway Source:UniProtKB
Biological Process positive regulation of reciprocal meiotic recombination Source:Ensembl
Biological Process postreplication repair Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein autoubiquitination Source:UniProtKB1 Publication
Biological Process protein K11-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein monoubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:UniProtKB1 Publication
Biological Process protein stabilization Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:UniProtKB2 Publications
Biological Process regulation of histone modification Source:Ensembl
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process response to xenobiotic stimulus Source:UniProtKB1 Publication
Biological Process sperm axoneme assembly Source:Ensembl
Biological Process spermatogenesis Source:UniProtKB1 Publication
Biological Process synaptonemal complex organization Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication

Cell membrane
Nucleus
In peripheral neurons, expressed both at the plasma membrane and in nuclei.