Mouse Anti-UBE4B Recombinant Antibody (CBFYU-177) (CBMAB-U0177-FY)

Name: Mouse Anti-UBE4B Recombinant Antibody (CBFYU-177)
SKU: CBMAB-U0177-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYU-177

Application

WB, ELISA

Immunogen

Partial recombinant corresponding to aa1075-1173 from UBE4B (NP_006039) with GST tag. MW of the GST tag alone is 26 kD.

Specificity

Human

Antibody Isotype

IgG1, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1075-1174

More Infomation

Target

Full Name

ubiquitination factor E4B (UFD2 homolog, yeast)

Introduction

This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Entrez Gene ID

10277

UniProt ID

O95155

Alternative Names

E4; UFD2; HDNB1; UBOX3; UFD2A

Function

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity).
May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity).
May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820).

Biological Process

Biological Process granzyme-mediated apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:MGI1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus

PTM

Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-UBE4B Recombinant Antibody (CBFYU-176) (CAT#: CBMAB-U0176-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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