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Mouse Anti-ULK3 Recombinant Antibody (1404CT148-89-25) (CBMAB-C4627-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1404CT148-89-25
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
KLH-conjugated synthetic peptide between amino acids 435-468 from C-terminal region of human ULK3.ImmunogenType: Synthetic peptide
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Unc-51 Like Kinase 3
Introduction
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Entrez Gene ID
25989
UniProt ID
Q6PHR2
Alternative Names
Unc-51 Like Kinase 3; Unc-51-Like Kinase 3 (C. Elegans); Unc-51-Like Kinase 3; EC 2.7.11.1;
Function
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Biological Process
Biological Process autophagosome organization Source:GO_Central1 Publication
Biological Process autophagy Source:UniProtKB1 Publication
Biological Process cellular senescence Source:UniProtKB1 Publication
Biological Process fibroblast activation Source:CACAO1 Publication
Biological Process negative regulation of smoothened signaling pathway Source:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process positive regulation of smoothened signaling pathway Source:UniProtKB2 Publications
Biological Process protein autophosphorylation Source:UniProtKB2 Publications
Biological Process smoothened signaling pathway Source:FlyBase1 Publication
Cellular Location
Cytoplasm
Localizes to pre-autophagosomal structure during cellular senescence.
PTM
Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU.
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For research use only. Not intended for any clinical use.

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