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Mouse Anti-ULK3 Recombinant Antibody (CBT3307) (V2LY-0625-LY1926)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBT3307
Antibody Isotype
IgG1
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human ULK3 expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:50-1:200
FC1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Unc-51 Like Kinase 3
Entrez Gene ID
25989
Function
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Biological Process
Biological Process autophagosome organization Source:GO_Central1 Publication
Biological Process autophagy Source:UniProtKB1 Publication
Biological Process cellular senescence Source:UniProtKB1 Publication
Biological Process fibroblast activation Source:CACAO1 Publication
Biological Process negative regulation of smoothened signaling pathway Source:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process positive regulation of smoothened signaling pathway Source:UniProtKB2 Publications
Biological Process protein autophosphorylation Source:UniProtKB2 Publications
Biological Process smoothened signaling pathway Source:FlyBase1 Publication
Cellular Location
Cytoplasm
Localizes to pre-autophagosomal structure during cellular senescence.
PTM
Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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