Mouse Anti-USP53 (aa 495-582) Recombinant Antibody (3C9) (CBMAB-U0070-CQ)

Name: Mouse Anti-USP53 (aa 495-582) Recombinant Antibody (3C9)
SKU: CBMAB-U0070-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3C9

Application

Immunogen

Recombinant protein fragment between amino acids 495-582 of human USP53 produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Purity

>95% as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 495-582

More Infomation

Target

Full Name

Ubiquitin Specific Peptidase 53

Introduction

USP53 is a novel tight junction-associated protein that is essential for the survival of auditory hair cells and normal hearing in mice, possibly by modulating the barrier properties and mechanical stability of tight junctions.

Entrez Gene ID

54532

UniProt ID

Q70EK8

Alternative Names

USP53; ubiquitin specific peptidase 53; ubiquitin specific protease 53; inactive ubiquitin carboxyl-terminal hydrolase 53; KIAA1350; ubiquitin specific proteinase 53; inactive ubiquitin-specific peptidase 53; DKFZp781E1417

Function

Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions. Has no peptidase activity (PubMed:14715245).

Biological Process

Biological Process protein deubiquitination Source:InterPro
Biological Process response to auditory stimulus Source:GO_Central1 Publication
Biological Process sensory perception of sound Source:GO_Central1 Publication

Cellular Location

Cell junction, tight junction

Involvement in disease

Cholestasis, progressive familial intrahepatic, 7, with or without hearing loss (PFIC7):
An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. Some PFIC7 patients develop hearing loss in childhood.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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