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Mouse Anti-USP53 (aa 495-582) Recombinant Antibody (3C9) (CBMAB-U0070-CQ)

This product is a mouse antibody that recognizes USP53 (aa 495-582). The antibody 3C9 can be used for immunoassay techniques such as: WB.
See all USP53 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C9
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant protein fragment between amino acids 495-582 of human USP53 produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 495-582

Target

Full Name
Ubiquitin Specific Peptidase 53
Introduction
USP53 is a novel tight junction-associated protein that is essential for the survival of auditory hair cells and normal hearing in mice, possibly by modulating the barrier properties and mechanical stability of tight junctions.
Entrez Gene ID
54532
UniProt ID
Q70EK8
Alternative Names
USP53; ubiquitin specific peptidase 53; ubiquitin specific protease 53; inactive ubiquitin carboxyl-terminal hydrolase 53; KIAA1350; ubiquitin specific proteinase 53; inactive ubiquitin-specific peptidase 53; DKFZp781E1417
Function
Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions. Has no peptidase activity (PubMed:14715245).
Biological Process
Biological Process protein deubiquitination Source:InterPro
Biological Process response to auditory stimulus Source:GO_Central1 Publication
Biological Process sensory perception of sound Source:GO_Central1 Publication
Cellular Location
Cell junction, tight junction
Involvement in disease
Cholestasis, progressive familial intrahepatic, 7, with or without hearing loss (PFIC7):
An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. Some PFIC7 patients develop hearing loss in childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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