Mouse Anti-WIPF1 Recombinant Antibody (K32-824) (CBMAB-W0330-WJ)

Name: Mouse Anti-WIPF1 Recombinant Antibody (K32-824)
SKU: CBMAB-W0330-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

K32-824

Application

Immunogen

Phosphorylated human WIP peptide.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WAS/WASL interacting protein family, member 1

Introduction

WIPF1 is a protein-coding gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. This protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Diseases associated with WIPF1 include Wiskott-Aldrich Syndrome 2 and Wiskott-Aldrich Syndrome. Gene Ontology (GO) annotations related to this gene include actin binding and profilin binding.

Entrez Gene ID

Human	7456
Mouse	215280
Rat	117538

UniProt ID

Human	O43516
Mouse	Q8K1I7
Rat	Q6IN36

Alternative Names

WAS/WASL interacting protein family member 1

Function

Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity).
Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.

Biological Process

Biological Process actin filament-based movement Source:GO_Central1 Publication
Biological Process actin polymerization or depolymerization Source:ProtInc1 Publication
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process response to other organism Source:Ensembl

Cellular Location

Cytoplasmic vesicle
Cytoplasm, cytoskeleton
Cell projection, ruffle
Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).

Involvement in disease

Wiskott-Aldrich syndrome 2 (WAS2):
An immunodeficiency disorder characterized by eczema, thrombocytopenia, recurrent infections, defective T-cell proliferation, and impaired natural killer cell function.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Human Anti-WIPF1 Recombinant Antibody (CBWJW-173) (CAT#: CBMAB-W0316-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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