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Rat Anti-WNT10A Recombinant Antibody (CBWJW-120) (CBMAB-W0269-WJ)

This product is a rat antibody that recognizes WNT10A. The antibody CBWJW-120 can be used for immunoassay techniques such as: WB.
See all WNT10A antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
CBWJW-120
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant mouse Wnt-10a, Leu55-Glu95 and Gln278-Arg360.
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Wnt Family Member 10A
Introduction
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. Diseases associated with WNT10A include Schopf-Schulz-Passarge Syndrome and Odontoonychodermal Dysplasia. An important paralog of this gene is WNT10B.
Entrez Gene ID
Human80326
Mouse22409
UniProt ID
HumanQ9GZT5
MouseP70701
Alternative Names
OODD; SSPS; STHAG4
Function
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).
Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954).
Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954).
Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954).
Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity).
Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954).
Required for normal hair follicle function (PubMed:28589954).
Biological Process
Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to transforming growth factor beta stimulus Source:UniProtKB1 Publication
Biological Process epidermis morphogenesis Source:BHF-UCL1 Publication
Biological Process hair follicle development Source:BHF-UCL2 Publications
Biological Process hair follicle morphogenesis Source:BHF-UCL1 Publication
Biological Process neural crest cell differentiation Source:Ensembl
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process odontogenesis Source:BHF-UCL2 Publications
Biological Process positive regulation of gene expression Source:Ensembl
Biological Process regulation of odontogenesis of dentin-containing tooth Source:Ensembl
Biological Process sebaceous gland development Source:BHF-UCL1 Publication
Biological Process skin development Source:BHF-UCL2 Publications
Biological Process tongue development Source:BHF-UCL2 Publications
Cellular Location
Secreted, extracellular space, extracellular matrix
Secreted
Involvement in disease
Odonto-onycho-dermal dysplasia (OODD):
A rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin.
Schopf-Schulz-Passarge syndrome (SSPS):
A rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms.
Tooth agenesis, selective, 4 (STHAG4):
A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped. Some STHAG4 patients manifest mild features of ectodermal dysplasia, including sparse hair, sparse eyebrows, short eyelashes, abnormalities of the nails, sweating anomalies and dry skin. STHAG4 inheritance is autosomal dominant or autosomal recessive.
PTM
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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