WNT10A

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.

Wnt Family Member 10A

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).
Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954).
Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954).
Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954).
Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity).
Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954).
Required for normal hair follicle function (PubMed:28589954).

Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to transforming growth factor beta stimulus Source:UniProtKB1 Publication
Biological Process epidermis morphogenesis Source:BHF-UCL1 Publication
Biological Process hair follicle development Source:BHF-UCL2 Publications
Biological Process hair follicle morphogenesis Source:BHF-UCL1 Publication
Biological Process neural crest cell differentiation Source:Ensembl
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process odontogenesis Source:BHF-UCL2 Publications
Biological Process positive regulation of gene expression Source:Ensembl
Biological Process regulation of odontogenesis of dentin-containing tooth Source:Ensembl
Biological Process sebaceous gland development Source:BHF-UCL1 Publication
Biological Process skin development Source:BHF-UCL2 Publications
Biological Process tongue development Source:BHF-UCL2 Publications

Secreted, extracellular space, extracellular matrix
Secreted

Odonto-onycho-dermal dysplasia (OODD):
A rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin.
Schopf-Schulz-Passarge syndrome (SSPS):
A rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms.
Tooth agenesis, selective, 4 (STHAG4):
A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped. Some STHAG4 patients manifest mild features of ectodermal dysplasia, including sparse hair, sparse eyebrows, short eyelashes, abnormalities of the nails, sweating anomalies and dry skin. STHAG4 inheritance is autosomal dominant or autosomal recessive.

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.