Mouse Anti-WWOX Recombinant Antibody (3D10) (CBMAB-BR494LY)
Compare
Online Inquiry
Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Biological Process extrinsic apoptotic signaling pathway Source:Ensembl
Biological Process intrinsic apoptotic signaling pathway by p53 class mediator Source:Ensembl
Biological Process negative regulation of Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process osteoblast differentiation Source:Ensembl
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:BHF-UCL
Biological Process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL
Biological Process skeletal system morphogenesis Source:BHF-UCL
Biological Process Wnt signaling pathway Source:UniProtKB-KW
Nucleus
Mitochondrion
Golgi apparatus
Partially localizes to the mitochondria (PubMed:14695174).
Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity).
Translocates to the nucleus in response to TGFB1 (PubMed:19366691).
Isoform 5 and isoform 6 may localize in the nucleus.
A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
Spinocerebellar ataxia, autosomal recessive, 12 (SCAR12):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR12 is additionally characterized by onset of generalized seizures in infancy, and delayed psychomotor development with intellectual disability. Some patients may also show spasticity.
Developmental and epileptic encephalopathy 28 (DEE28):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
Ubiquitinated when phosphorylated by TNK2, leading to its degradation.
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon
$30 eGift Card
Submit a review
Loading...
Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
Online InquiryContact us
