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Mouse Anti- YAP1 Recombinant Antibody (8J19) (CBMAB-0505-LY)

This product is mouse antibody recognizes YAP1 of mouse. The antibody 8J19 immunoassay techniques such as: IP.
Host Species
Mouse
Application
IP
Antibody Isotype
IgG2a
Specificity
Mouse, Human, Rat
Clone
8J19
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. Plays a key role to control cell proliferation in response to cell contact.
Alternative Name
Yap; Yap65; Yki; Yorkie
Entrez Gene ID
UniProt ID
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For research use only. Not intended for any clinical use.
Cat CBMAB-0505-LY
Conjugates
Size
Price $
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Second antibody and isotype control