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Mouse Anti-ZDHHC3 Recombinant Antibody (CBLG1-3250) (CBMAB-G6693-LY)

This product is antibody recognizes ZDHHC3. The antibody CBLG1-3250 immunoassay techniques such as: WB.
See all ZDHHC3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-3250
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Zinc Finger DHHC-Type Containing 3
Introduction
Palmitoyltransferase with broad specificity (PubMed:21926431, PubMed:23034182). Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (By similarity). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25 (By similarity).
Entrez Gene ID
51304
UniProt ID
Q9NYG2
Alternative Names
DHHC-3; DHHC3; GODZ; ZNF373
Function
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500).
Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).
Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095).
Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500).
Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897).
In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity).
Could also palmitoylate the D2 dopamine receptor DRD2 (PubMed:26535572).
May also function as a calcium transporter.
Biological Process
Biological Process lipoprotein localization to membrane Source:UniProtKB1 Publication
Biological Process peptidyl-L-cysteine S-palmitoylation Source:UniProtKB
Biological Process positive regulation of receptor localization to synapse Source:UniProtKB
Biological Process positive regulation of synaptic transmission, GABAergic Source:UniProtKB
Biological Process protein localization to photoreceptor outer segment Source:MGI1 Publication
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein palmitoylation Source:UniProtKB2 Publications
Biological Process protein targeting to membrane Source:GO_Central1 Publication
Biological Process regulation of G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:UniProtKB1 Publication
Cellular Location
Golgi apparatus membrane
Localizes to the Golgi cis cisterna.
Topology
Cytoplasmic: 1-47
Helical: 48-68
Extracellular: 69-72
Helical: 73-93
Cytoplasmic: 94-171
Helical: 172-192
Extracellular: 193-214
Helical: 215-235
Cytoplasmic: 236-299
PTM
Autopalmitoylated.
Phosphorylation by FGFR1 and SRC probably regulates the palmitoyltransferase activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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