bad, BIM, cIAP-2, HSP27, IGF-2, IGFBP-5, p27, TNF RII (TNFRSF1B), TRAIL R3 (TNFRSF10C), bax, Caspase-3, Cytochrome C, HSP60, IGFBP-1, IGFBP-6, p53, TNF alpha, TRAIL R4 (TNFRSF10D), bcl-2, Caspase-8, DR6 (TNFRSF21), HSP70, IGFBP-2, IGF-1 R, SMAC, TNF beta (TNFSF1B), XIAP, bcl-w, CD40 (TNFRSF5), Fas (TNFRSF6/Apo-1), HTRA2, IGFBP-3, livin, Survivin (BIRC5), TRAIL R1 (TNFRSF10A/DR4), BID, CD40 Ligand (TNFSF5), Fas Ligand (TNFSF6), IGF-1, IGFBP-4, p21, TNF RI (TNFRSF1A), TRAIL R2 (TNFRSF10B/DR5)
Serum, Plasma, Cell Culture Supernatant, Cell Lysates, Tissue Lysates
Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between the ages of 8 to 14 year old approximately 20 to 30 billion cells die per day.