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GRB7 Matched Antibody Pair (498) (APMAB-498LY)

This antibody pair set can be used for detecting and quantifying protein level of human GRB7.
See all GRB7 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-GRB7 monoclonal antibody, 100 ug
Detection Antibody
Anti-GRB7 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Alternative Names
Growth Factor Receptor Bound Protein 7; Growth Factor Receptor-Bound Protein 7; Epidermal Growth Factor Receptor GRB-7; GRB7 Adapter Protein; B47;
Entrez Gene ID
2886
UniProt ID
Q14451

Chauhan, A., & Kalra, S. (2023). Erb-b2 receptor tyrosine kinase 2 interaction with growth factor receptor bound protein 7 acts as a molecular switch to activate non-small cell lung cancer: An in silico prediction. Biomedical and Biotechnology Research Journal (BBRJ), 7(1), 111.

Xu, Q., Liu, Z., Zhu, Z. Q., Fan, Y., Chen, R., Xie, X. H., & Cheng, M. (2021). Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells. Bioengineered, 12(2), 12179-12190.

Zheng, Y., Pei, Y., Yang, L., Zeng, Z., Wang, J., Xie, G., ... & Yuan, J. (2020). Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway. International Journal of Biological Sciences, 16(16), 3221.

Tang, H., Yang, P., Yang, X., Peng, S., Hu, X. E., & Bao, G. (2020). Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling. Molecular and Cellular Biochemistry, 472, 209-218.

Gotovac, J. R., Liu, D. S., Yates, M. J., Milne, J. V., Macpherson, A. A., Simpson, K. J., ... & Clemons, N. J. (2020). GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma. The Journal of Pathology, 252(3), 317-329.

Chu, P. Y., Tai, Y. L., & Shen, T. L. (2019). Grb7, a critical mediator of EGFR/ErbB signaling, in cancer development and as a potential therapeutic target. Cells, 8(5), 435.

Tang, Y., Yang, S., Wang, M., Liu, D., Liu, Y., Zhang, Y., & Zhang, Q. (2019). Epigenetically altered miR‑193a‑3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7. International Journal of Molecular Medicine, 43(6), 2352-2360.

Chen, K., Liu, M. X., Mak, C. S. L., Yung, M. M. H., Leung, T. H. Y., Xu, D., ... & Chan, D. W. (2018). Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways. Theranostics, 8(2), 423.

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For research use only. Not intended for any clinical use.

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