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Mouse Anti-GRK2 Recombinant Antibody (6C1-D9-C0) (CBMAB-Z0287-LY)

The product is antibody recognizes GRK2. The antibody 6C1-D9-C0 immunoassay techniques such as: WB, IHC, ICC.
See all GRK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
6C1-D9-C0
Antibody Isotype
IgG1
Application
WB, IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of human GRK2 expressed in E. Coli.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor kinase 2
Entrez Gene ID
Human156
Mouse110355
Rat25238
Monkey721754
UniProt ID
HumanP25098
MouseQ99MK8
RatP26817
MonkeyH9FQI5
Alternative Names
GRK2; BARK1; FLJ16718; BETA-ARK1; ADRBK1
Function
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378).

Key regulator of LPAR1 signaling (PubMed:19306925).

Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925).

Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925).

Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).

Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927).
Biological Process
Cardiac muscle contraction Source: BHF-UCL
Desensitization of G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled acetylcholine receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: GO_Central
Heart development Source: Ensembl
Negative regulation of relaxation of smooth muscle Source: UniProtKB
Negative regulation of striated muscle contraction Source: BHF-UCL
Negative regulation of the force of heart contraction by chemical signal Source: BHF-UCL
Peptidyl-serine phosphorylation Source: BHF-UCL
Peptidyl-threonine phosphorylation Source: Ensembl
Positive regulation of catecholamine secretion Source: BHF-UCL
Protein phosphorylation Source: GO_Central
Receptor internalization Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Regulation of the force of heart contraction Source: GO_Central
Tachykinin receptor signaling pathway Source: BHF-UCL
Viral entry into host cell Source: CACAO
Viral genome replication Source: CACAO
Cellular Location
Cell membrane; Cytoplasm

Davis, K., Mitchell, C., Weissenfels, O., Bai, J., Raizen, D. M., Ailion, M., & Topalidou, I. (2023). G protein-coupled receptor kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans. PLoS genetics, 19(1), e1010613.

Crudden, C., Shibano, T., Song, D., Dragomir, M. P., Cismas, S., Serly, J., ... & Girnita, L. (2021). Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell GrowthUnbiased IGF1R Downregulation through GRK2 Inhibition. Cancer research, 81(2), 501-514.

Xu, G., Gaul, M. D., Liu, Z., DesJarlais, R. L., Qi, J., Wang, W., ... & Spurlino, J. C. (2020). Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorganic & Medicinal Chemistry Letters, 30(23), 127602.

Kang, J. H., Toita, R., Kawano, T., Murata, M., & Asai, D. (2020). Design of substrates and inhibitors of G protein-coupled receptor kinase 2 (GRK2) based on its phosphorylation reaction. Amino Acids, 52, 863-870.

Gambardella, J., Sorriento, D., Bova, M., Rusciano, M., Loffredo, S., Wang, X., ... & Ciccarelli, M. (2020). Role of endothelial G protein-coupled receptor kinase 2 in angioedema. Hypertension, 76(5), 1625-1636.

Murga, C., Arcones, A. C., Cruces-Sande, M., Briones, A. M., Salaices, M., & Mayor Jr, F. (2019). G protein-coupled receptor kinase 2 (GRK2) as a potential therapeutic target in cardiovascular and metabolic diseases. Frontiers in pharmacology, 10, 112.

Penela, P., Ribas, C., Sánchez-Madrid, F., & Mayor, F. (2019). G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub. Cellular and Molecular Life Sciences, 76, 4423-4446.

Mayor Jr, F., Cruces-Sande, M., Arcones, A. C., Vila-Bedmar, R., Briones, A. M., Salaices, M., & Murga, C. (2018). G protein-coupled receptor kinase 2 (GRK2) as an integrative signalling node in the regulation of cardiovascular function and metabolic homeostasis. Cellular Signalling, 41, 25-32.

Cruces-Sande, M., Vila-Bedmar, R., Arcones, A. C., Gonzalez-Rodriguez, A., Rada, P., Gutierrez-de-Juan, V., ... & Murga, C. (2018). Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(12), 3655-3667.

Pfleger, J., Gross, P., Johnson, J., Carter, R. L., Gao, E., Tilley, D. G., ... & Koch, W. J. (2018). G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart. Journal of molecular and cellular cardiology, 123, 108-117.

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For research use only. Not intended for any clinical use.

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