GRK2

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.
Full Name
G protein-coupled receptor kinase 2
Function
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378).

Key regulator of LPAR1 signaling (PubMed:19306925).

Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925).

Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925).

Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).

Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927).
Biological Process
Cardiac muscle contraction Source: BHF-UCL
Desensitization of G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled acetylcholine receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: GO_Central
Heart development Source: Ensembl
Negative regulation of relaxation of smooth muscle Source: UniProtKB
Negative regulation of striated muscle contraction Source: BHF-UCL
Negative regulation of the force of heart contraction by chemical signal Source: BHF-UCL
Peptidyl-serine phosphorylation Source: BHF-UCL
Peptidyl-threonine phosphorylation Source: Ensembl
Positive regulation of catecholamine secretion Source: BHF-UCL
Protein phosphorylation Source: GO_Central
Receptor internalization Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Regulation of the force of heart contraction Source: GO_Central
Tachykinin receptor signaling pathway Source: BHF-UCL
Viral entry into host cell Source: CACAO
Viral genome replication Source: CACAO
Cellular Location
Cell membrane; Cytoplasm
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Anti-GRK2 antibodies

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Mouse Anti-GRK2 Recombinant Antibody (CAP857) (CBMAB-AP2617LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CAP857
Application*: WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (CAP223) (CBMAB-AP543LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP223
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (CAP078) (CBMAB-AP178LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse, Pig, Dog
Clone: CAP078
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (CB439A) (CBMAB-CA439LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse, Pig, Dog
Clone: CB439A
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (6C1-D9-C0) (CBMAB-Z0287-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 6C1-D9-C0
Application*: WB, IH, IC
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (CBYC-A972) (CBMAB-A4452-YC)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-A972
Application*: E, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (8H208) (CBMAB-A4450-YC)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 8H208
Application*: WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (3G3) (CBMAB-A4448-YC)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: 3G3
Application*: E, IC, IF, IH, WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (13B354) (CBMAB-A4445-YC)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B354
Application*: E, IH, WB
Datasheet SDS

Rabbit Anti-GRK2 Recombinant Antibody (CBLG1-1782) (CBMAB-G4992-LY)

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Target: GRK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-1782
Application*: WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (3F8) (CBMAB-G4987-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human, Monkey
Clone: 3F8
Application*: WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (CBLG1-1781) (CBMAB-G4991-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1781
Application*: WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (5D5) (CBMAB-G4989-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 5D5
Application*: IC/IF, IH, WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (13k60) (CBMAB-G4986-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 13k60
Application*: WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (466717) (CBMAB-G0802-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 466717
Application*: WB
Datasheet SDS

Rabbit Anti-GRK2 Recombinant Antibody (2089B) (CBMAB-G0801-LY)

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Target: GRK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 2089B
Application*: WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (15B164) (CBMAB-G0800-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 15B164
Application*: WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (13A189) (CBMAB-G0799-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat, Human
Clone: 13A189
Application*: F
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (CBFYH-0485) (CBMAB-H1355-FY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Cattle
Clone: CBFYH-0485
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (
17B3) (V2LY-0725-LY445)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse, Pig, Dog
Clone: 17B3
Application*: E, WB
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (CBT630) (V2LY-0625-LY3377)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBT630
Application*: WB, P, IF, IC, E
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (CBT3220) (V2LY-0625-LY2629)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: CBT3220
Application*: WB, IH, IC
Datasheet SDS

Mouse Anti-GRK2 Recombinant Antibody (EG352) (CBMAB-EN389-LY)

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Target: GRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: EG352
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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