GRK2

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.

G protein-coupled receptor kinase 2

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378).

Key regulator of LPAR1 signaling (PubMed:19306925).

Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925).

Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925).

Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).

Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927).

Cardiac muscle contraction Source: BHF-UCL
Desensitization of G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled acetylcholine receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: GO_Central
Heart development Source: Ensembl
Negative regulation of relaxation of smooth muscle Source: UniProtKB
Negative regulation of striated muscle contraction Source: BHF-UCL
Negative regulation of the force of heart contraction by chemical signal Source: BHF-UCL
Peptidyl-serine phosphorylation Source: BHF-UCL
Peptidyl-threonine phosphorylation Source: Ensembl
Positive regulation of catecholamine secretion Source: BHF-UCL
Protein phosphorylation Source: GO_Central
Receptor internalization Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Regulation of the force of heart contraction Source: GO_Central
Tachykinin receptor signaling pathway Source: BHF-UCL
Viral entry into host cell Source: CACAO
Viral genome replication Source: CACAO

Cell membrane; Cytoplasm