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Mouse Anti-GSTM1 Recombinant Antibody (3G8-C3-D5) (CBMAB-Z0509-LY)

The product is antibody recognizes GSTM1. The antibody 3G8-C3-D5 immunoassay techniques such as: WB, IHC, FC.
See all GSTM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
3G8-C3-D5
Antibody Isotype
IgG1
Application
WB, IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human GSTM1 expressed in E. Coli.
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutathione S-transferase mu 1
Entrez Gene ID
Human2944
Rat24423
UniProt ID
HumanP09488
RatP04905
Alternative Names
MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).
Biological Process
Cellular detoxification of nitrogen compound Source: BHF-UCL
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: BHF-UCL
Hepoxilin biosynthetic process Source: UniProtKB
Nitrobenzene metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic catabolic process Source: BHF-UCL
Cellular Location
Cytoplasm

Nakanishi, G., Bertagnolli, L. S., Pita-Oliveira, M., Scudeler, M. M., Torres-Loureiro, S., Almeida-Dantas, T., ... & Rodrigues-Soares, F. (2022). GSTM1 and GSTT1 polymorphisms in healthy volunteers–a worldwide systematic review. Drug Metabolism Reviews, 54(1), 37-45.

Levy, R. V., Reidy, K. J., Le, T. H., David, V., Winkler, C., Xu, Y., ... & Melamed, M. L. (2022). Association of GSTM1 deletion with progression of CKD in children: Findings from the chronic kidney disease in children (CKiD) study. American Journal of Kidney Diseases, 80(1), 79-86.

Abbas, M., Verma, S., Verma, S., Siddiqui, S., Khan, F. H., Raza, S. T., ... & Mahdi, F. (2021). Association of GSTM1 and GSTT1 gene polymorphisms with COVID‐19 susceptibility and its outcome. Journal of medical virology, 93(9), 5446-5451.

Singh, P., Wang, X., Hageman, L., Chen, Y., Magdy, T., Landier, W., ... & Bhatia, S. (2020). Association of GSTM1 null variant with anthracycline‐related cardiomyopathy after childhood cancer—A Children's Oncology Group ALTE03N1 report. Cancer, 126(17), 4051-4058.

Chanhom, N., Udomsinprasert, W., Mahasirimongkol, S., Wattanapokayakit, S., & Jittikoon, J. (2020). GSTM1 and GSTT1 genetic polymorphisms and their association with antituberculosis drug‑induced liver injury. Biomedical Reports, 12(4), 153-162.

Song, L., Yang, C., & He, X. F. (2020). Individual and combined effects of GSTM1 and GSTT1 polymorphisms on colorectal cancer risk: an updated meta-analysis. Bioscience Reports, 40(8).

Li, S., Xue, F., Zheng, Y., Yang, P., Lin, S., Deng, Y., ... & Chen, S. (2019). GSTM1 and GSTT1 null genotype increase the risk of hepatocellular carcinoma: evidence based on 46 studies. Cancer cell international, 19(1), 1-12.

Kalacas, N. A., Garcia, J. A., Ortin, T. S., Valdez Jr, A., Fellizar, A., Ramos, M. C., & Albano, P. M. (2019). GSTM1 and GSTT1 genetic polymorphisms and breast cancer risk in selected Filipino cases. Asian Pacific journal of cancer prevention: APJCP, 20(2), 529.

Grubisa, I., Otasevic, P., Vucinic, N., Milicic, B., Jozic, T., Krstic, S., & Milasin, J. (2018). Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population. Genetics and molecular biology, 41, 35-40.

Klusek, J., Nasierowska-Guttmejer, A., Kowalik, A., Wawrzycka, I., Lewitowicz, P., Chrapek, M., & Głuszek, S. (2018). GSTM1, GSTT1, and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers. Oncotarget, 9(30), 21224.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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