GSTM1

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Full Name
glutathione S-transferase mu 1
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).
Biological Process
Cellular detoxification of nitrogen compound Source: BHF-UCL
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: BHF-UCL
Hepoxilin biosynthetic process Source: UniProtKB
Nitrobenzene metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic catabolic process Source: BHF-UCL
Cellular Location
Cytoplasm
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Anti-GSTM1 antibodies

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Mouse Anti-GSTM1 Recombinant Antibody (CBLG1-2015) (CBMAB-G5492-LY)

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Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2015
Application*: WB, P
Datasheet SDS

Mouse Anti-GSTM1 Recombinant Antibody (5) (CBMAB-G5489-LY)

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Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5
Application*: WB
Datasheet SDS

Mouse Anti-GSTM1 Recombinant Antibody (3B10) (CBMAB-G5487-LY)

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Target: GSTM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 3B10
Application*: E, IP, IF, WB, P, F
Datasheet SDS

Mouse Anti-GSTM1 Recombinant Antibody (10H6) (CBMAB-G5482-LY)

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Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 10H6
Application*: E, IH, WB, F
Datasheet SDS

Mouse Anti-GSTM1 Monoclonal Antibody (7A3) (CBMAB-1306CQ)

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Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7A3
Application*: E, IH, WB
Datasheet SDS

Human GSTM1 ELISA Kit (V2LY-0626-LY4115)

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Target: GSTM1
Sensitivity: 0.053 mU/mL
Detection Range: 0.1-40 mU/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-GSTM1 Recombinant Antibody (CBT3436) (V2LY-0625-LY2732)

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Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT3436
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-GSTM1 Recombinant Antibody (CBT3648) (V2LY-0625-LY2634)

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Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBT3648
Application*: WB, IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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