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GSTM1

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Full Name

glutathione S-transferase mu 1

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).

Biological Process

Cellular detoxification of nitrogen compound Source: BHF-UCL
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: BHF-UCL
Hepoxilin biosynthetic process Source: UniProtKB
Nitrobenzene metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic catabolic process Source: BHF-UCL

Cellular Location

Cytoplasm

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Anti-GSTM1 antibodies

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Mouse Anti-GSTM1 Recombinant Antibody (CBLG1-2015) (CBMAB-G5492-LY)

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Target: GSTM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-2015

Application*: WB, P

Mouse Anti-GSTM1 Recombinant Antibody (5) (CBMAB-G5489-LY)

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Target: GSTM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5

Application*: WB

Mouse Anti-GSTM1 Recombinant Antibody (3B10) (CBMAB-G5487-LY)

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Target: GSTM1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 3B10

Application*: E, IP, IF, WB, P, F

Mouse Anti-GSTM1 Recombinant Antibody (10H6) (CBMAB-G5482-LY)

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Target: GSTM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: 10H6

Application*: E, IH, WB, F

Mouse Anti-GSTM1 Monoclonal Antibody (7A3) (CBMAB-1306CQ)

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Target: GSTM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7A3

Application*: E, IH, WB

Mouse Anti-GSTM1 Recombinant Antibody (CBT3436) (V2LY-0625-LY2732)

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Target: GSTM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBT3436

Application*: WB, IH, F

Mouse Anti-GSTM1 Recombinant Antibody (CBT3648) (V2LY-0625-LY2634)

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Target: GSTM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: CBT3648

Application*: WB, IH, F

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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