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GSTM1

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Full Name
glutathione S-transferase mu 1
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).
Biological Process
Cellular detoxification of nitrogen compound Source: BHF-UCL
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: BHF-UCL
Hepoxilin biosynthetic process Source: UniProtKB
Nitrobenzene metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic catabolic process Source: BHF-UCL
Cellular Location
Cytoplasm

Anti-GSTM1 antibodies

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Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G9B9
Application*: WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 842516
Application*: WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 13B360
Application*: E, F
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 13B361
Application*: E, F
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 1H4F2
Application*: C, E, P, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B10
Application*: E
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-2014
Application*: SE, E
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBLG1-2015
Application*: WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2017
Application*: E, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBLG1-2018
Application*: WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBLG1-2020
Application*: E, IH, IP, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2021
Application*: E, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBLG1-2024
Application*: WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-2026
Application*: E
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2027
Application*: E, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBLG1-2028
Application*: E, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2029
Application*: WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 1H4-A4-A2
Application*: WB, IH, F
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7BA5
Application*: WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 11F2
Application*: FC, IHC, ICC, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Application*: FC
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7BA3
Application*: E, P, IH, M, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7BA4
Application*: E, P, IH, M, WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 10H6
Application*: P
Target: GSTM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 524CT17.2.5
Application*: WB
Target: GSTM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 3G8-C3-D5
Application*: WB, IH, F
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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