Human Recombinant CDH8 protein, His Tag (V2LY-0526-LY2484)

Name: Human Recombinant CDH8 protein, His Tag
SKU: V2LY-0526-LY2484
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CDH8 protein, His Tag consist of Amino Acid: 1-621 and predicts a molecular mass of 66.6 kDa.

Molecule Mass

66.6 kDa

Sequence

Amino Acid: 1-621

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cadherin 8

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central
Regulation of synapse organization Source: Ensembl
Response to cold Source: Ensembl
Synaptic transmission, glutamatergic Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 62-621
Helical: 622-642
Cytoplasmic: 643-799

Frei, J. A., Niescier, R. F., Bridi, M. S., Durens, M., Nestor, J. E., Kilander, M. B., ... & Lin, Y. C. (2021). Regulation of neural circuit development by cadherin-11 provides implications for autism. Eneuro.

Frei, J. A., Niescier, R. F., Bridi, M. S., Durens, M., Nestor, J. E., Yuan, X., ... & Lin, Y. C. (2020). Altered expression of cadherin-8 and cadherin-11 in neural circuit development: Implications for autism. BiorXiv.

Memi, F., Killen, A. C., Barber, M., Parnavelas, J. G., & Andrews, W. D. (2019). Cadherin 8 regulates proliferation of cortical interneuron progenitors. Brain Structure and Function, 224(1), 277-292.

Peng, D., Wan, D., Cheng, C., Ye, X., & Sun, M. (2018). Nematode-specific cadherin CDH-8 acts as a receptor for Cry5B toxin in Caenorhabditis elegans. Applied microbiology and biotechnology, 102(8), 3663-3673.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Recombinant CDH8 protein (CAT#: V2LY-0526-LY9189)

Rat Recombinant CDH8 protein, His Tag (CAT#: V2LY-0526-LY9190)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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