Human Recombinant STX3 protein, His Tag (V2LY-0526-LY7038)

Syntaxin 3

Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles.
Isoform B
Essential for survival of retinal photoreceetors.
Isoform 3
Functions as a regulator of gene expression.

Biological Process exocytic insertion of neurotransmitter receptor to postsynaptic membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic potentiationIEA:Ensembl
Biological Process neuron projection developmentISS:HGNC-UCL
Biological Process organelle membrane fusionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central

Isoform A
Apical cell membrane
Localized to the inner and outer plexiform layers, the cell body and the inner segments of photoreceptors.
Isoform 3
Nucleus

Retinal dystrophy and microvillus inclusion disease (RDMVID):
An autosomal recessive disease characterized by early-onset, severe retinal dystrophy associated with intractable congenital diarrhea. Intestinal biopsies show loss of microvilli, microvillus inclusions, and accumulation of subapical vesicles in villus enterocytes.
Diarrhea 12, with microvillus atrophy (DIAR12):
An autosomal recessive congenital enteropathy characterized by intractable secretory diarrhea, resulting in severe dehydration and metabolic acidosis. DIAR12 can be diagnosed based on variable loss of brush-border microvilli, microvillus inclusions, and accumulation of subapical vesicles in villus enterocytes.

Cytoplasmic: 1-263
Helical: 264-284
Extracellular: 285-289