IL13 Matched Antibody Pair (614) (APMAB-614LY)

Name: IL13 Matched Antibody Pair (614)
SKU: APMAB-614LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-IL13 monoclonal antibody, 100 ug

Detection Antibody

Anti-IL13 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

Alternative Names

Interleukin 13

Entrez Gene ID

3596

UniProt ID

P35225

More Infomation

Jia, F., Zhao, Q., Shi, P., Liu, H., & Zhang, F. (2022). Dupilumab: Advances in the off‐label usage of IL4/IL13 antagonist in dermatoses. Dermatologic Therapy, 35(12), e15924.

Stern, L. A., Gholamin, S., Moraga, I., Yang, X., Saravanakumar, S., Cohen, J. R., ... & Brown, C. E. (2022). Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy. Proceedings of the National Academy of Sciences, 119(33), e2112006119.

Noto, C. N., Hoft, S. G., Bockerstett, K. A., Jackson, N. M., Ford, E. L., Vest, L. S., & DiPaolo, R. J. (2022). IL13 Acts directly on gastric epithelial cells to promote Metaplasia Development during Chronic Gastritis. Cellular and Molecular Gastroenterology and Hepatology, 13(2), 623-642.

Campanati, A., Orciani, M., Marani, A., Di Vincenzo, M., Magi, S., Gregoriou, S., ... & Offidani, A. (2022). Mesenchymal stem cells profile in adult atopic dermatitis and effect of IL4-IL13 inflammatory pathway inhibition In vivo: Prospective case-control study. journal of clinical medicine, 11(16), 4759.

Ramonell, R. P., & Iftikhar, I. H. (2020). Effect of anti-IL5, anti-IL5R, anti-IL13 therapy on asthma exacerbations: a network meta-analysis. Lung, 198, 95-103.

Hirano, I., Collins, M. H., Assouline-Dayan, Y., Evans, L., Gupta, S., Schoepfer, A. M., ... & HEROES Study Group. (2019). RPC4046, a monoclonal antibody against IL13, reduces histologic and endoscopic activity in patients with eosinophilic esophagitis. Gastroenterology, 156(3), 592-603.

Heiss, J. D., Jamshidi, A., Shah, S., Martin, S., Wolters, P. L., Argersinger, D. P., ... & Lonser, R. R. (2018). Phase I trial of convection-enhanced delivery of IL13-Pseudomonas toxin in children with diffuse intrinsic pontine glioma. Journal of Neurosurgery: Pediatrics, 23(3), 333-342.

Rahal, O. M., Wolfe, A. R., Mandal, P. K., Larson, R., Tin, S., Jimenez, C., ... & Woodward, W. A. (2018). Blocking interleukin (IL) 4-and IL13-mediated phosphorylation of STAT6 (Tyr641) decreases M2 polarization of macrophages and protects against macrophage-mediated radioresistance of inflammatory breast cancer. International Journal of Radiation Oncology* Biology* Physics, 100(4), 1034-1043.

Hamzei Taj, S., Le Blon, D., Hoornaert, C., Daans, J., Quarta, A., Praet, J., ... & Hoehn, M. (2018). Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke. Journal of neuroinflammation, 15, 1-17.

Venkataramani, S., Low, S., Weigle, B., Dutcher, D., Jerath, K., Menzenski, M., ... & Erb, K. J. (2018). Design and characterization of Zweimab and Doppelmab, high affinity dual antagonistic anti-TSLP/IL13 bispecific antibodies. Biochemical and biophysical research communications, 504(1), 19-24.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

IL13 Matched Antibody Pair (613) (CAT#: APMAB-613LY)

IL13 Matched Antibody Pair (615) (CAT#: APMAB-615LY)

IL13 Matched Antibody Pair (616) (CAT#: APMAB-616LY)

IL13 Matched Antibody Pair (617) (CAT#: APMAB-617LY)

Antibody Pairs

IL13 Matched Antibody Pair (613) (CAT#: APMAB-613LY)

IL13 Matched Antibody Pair (615) (CAT#: APMAB-615LY)

IL13 Matched Antibody Pair (616) (CAT#: APMAB-616LY)

IL13 Matched Antibody Pair (617) (CAT#: APMAB-617LY)

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IL13 Matched Antibody Pair (616) (CAT#: APMAB-616LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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