IL13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

Interleukin 13

Cytokine (PubMed:8096327, PubMed:8097324).

Inhibits inflammatory cytokine production (PubMed:8096327).

Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327).

May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324).

Positively regulates IL31RA expression in macrophages (By similarity).

Cellular response to cytokine stimulus Source: Ensembl
Cellular response to mechanical stimulus Source: Ensembl
Immune response Source: InterPro
Inflammatory response Source: ProtInc
Macrophage activation Source: ARUK-UCL
Microglial cell activation Source: Ensembl
Negative regulation of complement-dependent cytotoxicity Source: AgBase
Negative regulation of endothelial cell apoptotic process Source: AgBase
Negative regulation of inflammatory response Source: ARUK-UCL
Negative regulation of lung ciliated cell differentiation Source: BHF-UCL
Negative regulation of NAD(P)H oxidase activity Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Negative regulation of transforming growth factor beta production Source: Ensembl
Positive regulation of B cell proliferation Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of connective tissue growth factor production Source: Ensembl
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of immunoglobulin production Source: Ensembl
Positive regulation of interleukin-10 production Source: ARUK-UCL
Positive regulation of lung goblet cell differentiation Source: BHF-UCL
Positive regulation of macrophage activation Source: Ensembl
Positive regulation of mast cell degranulation Source: Ensembl
Positive regulation of pancreatic stellate cell proliferation Source: Ensembl
Positive regulation of protein secretion Source: Ensembl
Positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
Regulation of proton transport Source: Ensembl
Response to ethanol Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to nicotine Source: Ensembl

Secreted

Allergic rhinitis (ALRH):
A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.