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Rat Anti-IL13 Recombinant Antibody (JES10-5A2) (CBMAB-I0396-YY)

This product is Rat antibody that recognizes IL13. The antibody JES10-5A2 can be used for immunoassay techniques such as: ELISA, ELISpot, ICFC, IHC, Neut, WB
See all IL13 antibodies
Published Data
Fig.1 Intracellular cytokine levels of allergen-specific TCRtg T cells upon stimulation with different forms of allergen-specific or nonspecific APCs.
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Summary

Host Animal
Rat
Specificity
Human
Clone
JES10-5A2
Antibody Isotype
IgG1, κ
Application
ELISA, ELISpot, ICFC, IHC, Neut, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
1.0 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 13
Introduction
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Entrez Gene ID
3596
UniProt ID
P35225
Alternative Names
Interleukin 13
Function
Cytokine (PubMed:8096327, PubMed:8097324).

Inhibits inflammatory cytokine production (PubMed:8096327).

Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327).

May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324).

Positively regulates IL31RA expression in macrophages (By similarity).
Biological Process
Cellular response to cytokine stimulus Source: Ensembl
Cellular response to mechanical stimulus Source: Ensembl
Immune response Source: InterPro
Inflammatory response Source: ProtInc
Macrophage activation Source: ARUK-UCL
Microglial cell activation Source: Ensembl
Negative regulation of complement-dependent cytotoxicity Source: AgBase
Negative regulation of endothelial cell apoptotic process Source: AgBase
Negative regulation of inflammatory response Source: ARUK-UCL
Negative regulation of lung ciliated cell differentiation Source: BHF-UCL
Negative regulation of NAD(P)H oxidase activity Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Negative regulation of transforming growth factor beta production Source: Ensembl
Positive regulation of B cell proliferation Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of connective tissue growth factor production Source: Ensembl
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of immunoglobulin production Source: Ensembl
Positive regulation of interleukin-10 production Source: ARUK-UCL
Positive regulation of lung goblet cell differentiation Source: BHF-UCL
Positive regulation of macrophage activation Source: Ensembl
Positive regulation of mast cell degranulation Source: Ensembl
Positive regulation of pancreatic stellate cell proliferation Source: Ensembl
Positive regulation of protein secretion Source: Ensembl
Positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
Regulation of proton transport Source: Ensembl
Response to ethanol Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to nicotine Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Allergic rhinitis (ALRH):
A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.

Jia, F., Zhao, Q., Shi, P., Liu, H., & Zhang, F. (2022). Dupilumab: Advances in the off‐label usage of IL4/IL13 antagonist in dermatoses. Dermatologic Therapy, 35(12), e15924.

Stern, L. A., Gholamin, S., Moraga, I., Yang, X., Saravanakumar, S., Cohen, J. R., ... & Brown, C. E. (2022). Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy. Proceedings of the National Academy of Sciences, 119(33), e2112006119.

Noto, C. N., Hoft, S. G., Bockerstett, K. A., Jackson, N. M., Ford, E. L., Vest, L. S., & DiPaolo, R. J. (2022). IL13 Acts directly on gastric epithelial cells to promote Metaplasia Development during Chronic Gastritis. Cellular and Molecular Gastroenterology and Hepatology, 13(2), 623-642.

Campanati, A., Orciani, M., Marani, A., Di Vincenzo, M., Magi, S., Gregoriou, S., ... & Offidani, A. (2022). Mesenchymal stem cells profile in adult atopic dermatitis and effect of IL4-IL13 inflammatory pathway inhibition In vivo: Prospective case-control study. journal of clinical medicine, 11(16), 4759.

Ramonell, R. P., & Iftikhar, I. H. (2020). Effect of anti-IL5, anti-IL5R, anti-IL13 therapy on asthma exacerbations: a network meta-analysis. Lung, 198, 95-103.

Hirano, I., Collins, M. H., Assouline-Dayan, Y., Evans, L., Gupta, S., Schoepfer, A. M., ... & HEROES Study Group. (2019). RPC4046, a monoclonal antibody against IL13, reduces histologic and endoscopic activity in patients with eosinophilic esophagitis. Gastroenterology, 156(3), 592-603.

Heiss, J. D., Jamshidi, A., Shah, S., Martin, S., Wolters, P. L., Argersinger, D. P., ... & Lonser, R. R. (2018). Phase I trial of convection-enhanced delivery of IL13-Pseudomonas toxin in children with diffuse intrinsic pontine glioma. Journal of Neurosurgery: Pediatrics, 23(3), 333-342.

Rahal, O. M., Wolfe, A. R., Mandal, P. K., Larson, R., Tin, S., Jimenez, C., ... & Woodward, W. A. (2018). Blocking interleukin (IL) 4-and IL13-mediated phosphorylation of STAT6 (Tyr641) decreases M2 polarization of macrophages and protects against macrophage-mediated radioresistance of inflammatory breast cancer. International Journal of Radiation Oncology* Biology* Physics, 100(4), 1034-1043.

Hamzei Taj, S., Le Blon, D., Hoornaert, C., Daans, J., Quarta, A., Praet, J., ... & Hoehn, M. (2018). Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke. Journal of neuroinflammation, 15, 1-17.

Venkataramani, S., Low, S., Weigle, B., Dutcher, D., Jerath, K., Menzenski, M., ... & Erb, K. J. (2018). Design and characterization of Zweimab and Doppelmab, high affinity dual antagonistic anti-TSLP/IL13 bispecific antibodies. Biochemical and biophysical research communications, 504(1), 19-24.

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For research use only. Not intended for any clinical use.

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