ACTN1

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Full Name
Actinin Alpha 1
Alternative Names
Actinin Alpha 1; Alpha-Actinin Cytoskeletal Isoform; F-Actin Cross-Linking Protein; Non-Muscle Alpha-Actinin-1; Actinin 1 Smooth Muscle; Alpha-Actinin-1; BDPLT15;
Function
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Biological Process
Actin filament bundle assembly
Actin filament network formation
Actin filament organization
Focal adhesion assembly
Negative regulation of cellular component movement
Platelet degranulation
Platelet formation
Platelet morphogenesis
Regulation of apoptotic process
Cellular Location
Cytoskeleton; Cell membrane; Z line; Cell junction. Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures.
Involvement in disease
Bleeding disorder, platelet-type 15 (BDPLT15): An autosomal dominant form of macrothrombocytopenia. Affected individuals usually have no or only mild bleeding tendency, such as epistaxis. Laboratory studies show decreased numbers of large platelets and anisocytosis, but the platelets show no in vitro functional abnormalities.
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Anti-ACTN1 antibodies

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Rabbit Anti-ACTN1 Recombinant Antibody (V2-179634) (CBMAB-A0981-YC)

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Target: ACTN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Zebrafish
Clone: V2-179634
Application*: WB, IF
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (V2-179633) (CBMAB-A0979-YC)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Mouse, Chicken
Clone: V2-179633
Application*: WB, DID, IC, IF
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (V2-179630) (CBMAB-A0973-YC)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: V2-179630
Application*: IH, WB
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (V2-179629) (CBMAB-A0972-YC)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit
Clone: V2-179629
Application*: IC, IF, IH, WB
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (V2-12510) (CBMAB-1000-CN)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: V2-12510
Application*: WB, IF, IH, P
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (V2-12509) (CBMAB-0999-CN)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: V2-12509
Application*: WB, E
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (V2-12508) (CBMAB-0998-CN)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: V2-12508
Application*: WB, E, F
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (V2-12507) (CBMAB-0997-CN)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: V2-12507
Application*: WB
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (
4F7) (V2LY-0725-LY370)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 4F7
Application*: E, IH
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (CBT115) (V2LY-0625-LY3788)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBT115
Application*: P, IF
Datasheet SDS

Mouse Anti-ACTN1 Recombinant Antibody (EC8) (V2LY-0624-LY8)

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Target: ACTN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC8
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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