ADAM8

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

Full Name

ADAM Metallopeptidase Domain 8

Function

Possible involvement in extravasation of leukocytes.

Biological Process

Angiogenesis
Cell-cell adhesion
Cell morphogenesis
Cellular response to hypoxia
Extracellular matrix disassembly
Inflammatory response
Leukocyte migration involved in inflammatory response
Lymphocyte chemotaxis
Negative regulation of neuron apoptotic process
Neutrophil degranulation
Positive regulation of acute inflammatory response
Positive regulation of bone resorption
Positive regulation of cell adhesion
Positive regulation of cellular extravasation
Positive regulation of eosinophil migration
Positive regulation of fibronectin-dependent thymocyte migration
Positive regulation of innate immune response
Positive regulation of MAP kinase activity
Positive regulation of membrane protein ectodomain proteolysis
Positive regulation of neutrophil extravasation
Positive regulation of NF-kappaB transcription factor activity
Positive regulation of protein kinase B signaling
Positive regulation of protein processing
Positive regulation of protein secretion
Positive regulation of T cell differentiation in thymus
Positive regulation of thymocyte apoptotic process
Positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
Regulation of cell-cell adhesion

Cellular Location

Membrane

Topology

Extracellular: 17-655 aa
Helical: 656-676 aa
Cytoplasmic: 677-824 aa