ADCYAP1

ADCYAP1 is a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses.

Full Name

Adenylate Cyclase Activating Polypeptide 1

Function

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).

Biological Process

Activation of adenylate cyclase activity
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
ATP metabolic process
Behavioral fear response
cAMP-mediated signaling
Cell-cell signaling
Cellular response to glucocorticoid stimulus
Female pregnancy
G protein-coupled receptor signaling pathway
Histamine secretion
Insulin secretion
Negative regulation of acute inflammatory response to antigenic stimulus
Negative regulation of acute inflammatory response to non-antigenic stimulus
Negative regulation of glial cell proliferation
Negative regulation of GTPase activity
Negative regulation of inflammatory response to antigenic stimulus
Negative regulation of muscle cell apoptotic process
Negative regulation of potassium ion transport
Neuron projection development
Neuropeptide signaling pathway
Ovarian follicle development
Pituitary gland development
Positive regulation of cAMP-mediated signaling
Positive regulation of cell population proliferation
Positive regulation of chemokine (C-C motif) ligand 5 production
Positive regulation of cold-induced thermogenesis
Positive regulation of cytosolic calcium ion concentration
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of growth hormone secretion
Positive regulation of GTPase activity
Positive regulation of interleukin-6 production
Positive regulation of neuron projection development
Positive regulation of protein kinase activity
Positive regulation of somatostatin secretion
Positive regulation of synaptic transmission, glutamatergic
Positive regulation of transcription by RNA polymerase II
Regulation of G protein-coupled receptor signaling pathway
Regulation of oligodendrocyte progenitor proliferation
Regulation of postsynaptic membrane potential
Regulation of protein localization
Response to ethanol
Response to starvation
Sensory perception of pain

Cellular Location

Secreted