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AFM

This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. [provided by RefSeq, Jul 2008]

Full Name

Afamin

Function

Functions as carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier.

Biological Process

Protein stabilization
Protein transport within extracellular region
Vitamin transport

Cellular Location

Secreted

PTM

N-glycosylated; more than 90% of the glycans are sialylated.

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Anti-AFM antibodies

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Mouse Anti-AFM Recombinant Antibody (V2-634159) (CBMAB-AP185LY)

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Target: AFM

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-634159

Application*: ELISA, IF, IP, WB

Mouse Anti-AFM Recombinant Antibody (V2-180060) (CBMAB-A1470-YC)

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Target: AFM

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: V2-180060

Application*: WB, IC, P, E

Mouse Anti-AFM Recombinant Antibody (V2-180059) (CBMAB-A1469-YC)

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Target: AFM

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-180059

Application*: WB

Mouse Anti-AFM Recombinant Antibody (V2-180057) (CBMAB-A1467-YC)

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Target: AFM

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: V2-180057

Application*: E, WB, IP, IH, IF

Human AFM ELISA Kit (V2LY-0626-LY3832)

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Target: AFM

Sensitivity: 2.38 ng/mL

Detection Range: 5-600 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Rat Afm ELISA Kit (V2LY-0626-LY1528)

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Target: Afm

Sensitivity: 0.42 ng/mL

Detection Range: 1-300 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Rat

Assay Type: Sandwich

Reactivity: Rat

Human Recombinant AFM protein, His Tag (V2LY-0526-LY1956)

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Target: AFM

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-599

Tag: His Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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