ARFGAP3

The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

Full Name

ADP Ribosylation Factor GTPase Activating Protein 3

Function

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

Biological Process

COPI coating of Golgi vesicle Source: GO_Central
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Intracellular protein transport Source: UniProtKB
Protein secretion Source: UniProtKB
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: Reactome
Vesicle-mediated transport Source: UniProtKB

Cellular Location

Golgi apparatus membrane; Cytoplasm. Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.