CAMK1D

This gene encodes a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. The encoded protein may be involved in the regulation of granulocyte function through the chemokine signal transduction pathway. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq]

Full Name

calcium/calmodulin-dependent protein kinase ID

Function

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.

Biological Process

Inflammatory response Source: UniProtKB-KW
Negative regulation of apoptotic process Source: Ensembl
Nervous system development Source: UniProtKB-KW
Peptidyl-serine phosphorylation Source: GO_Central
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of CREB transcription factor activity Source: UniProtKB
Positive regulation of neuron projection development Source: UniProtKB
Positive regulation of neutrophil chemotaxis Source: UniProtKB
Positive regulation of phagocytosis Source: UniProtKB
Positive regulation of respiratory burst Source: UniProtKB
Regulation of dendrite development Source: UniProtKB
Regulation of granulocyte chemotaxis Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm. Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.