CAPN5

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]
Full Name
Calpain 5
Function
Calcium-regulated non-lysosomal thiol-protease.
Biological Process
Proteolysis Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Extracellular exosome; Cell surface; Cytoplasm; Focal adhesion
Involvement in disease
Vitreoretinopathy, neovascular inflammatory (VRNI): An autoimmune condition of the eye that sequentially mimics uveitis, retinitis pigmentosa, and proliferative diabetic retinopathy as it progresses to complete blindness. Patients present during the second or third decade of life with posterior uveitis and reduction of the electroretinogram b-wave. They become more symptomatic when cataracts, cystoid macular edema, and disk edema diminish visual acuity during the second stage. Severe vision loss begins during the third stage when proliferative retinal neovascularization and epiretinal membranes appear. There is an ongoing pigmentary retinal degeneration and peripheral visual field loss during all stages. In the fourth stage, proliferative vitreoretinopathy causes tractional retinal detachments at the macula and vitreous base. The fifth or end-stage disease is marked by phthisis.
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Anti-CAPN5 antibodies

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Rabbit Anti-CAPN5 Recombinant Antibody (CBXC-3044) (CBMAB-C3681-CQ)

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Target: CAPN5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXC-3044
Application*: IH, WB
Rabbit Anti-CAPN5 Recombinant Antibody (CBXC-3044)
Datasheet SDS

Mouse Anti-CAPN5 Recombinant Antibody (CBFYC-0798) (CBMAB-C0853-FY)

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Target: CAPN5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0798
Application*: WB, IP, IF, E, P
Mouse Anti-CAPN5 Recombinant Antibody (CBFYC-0798)
Datasheet SDS

Mouse Anti-CAPN5 Recombinant Antibody (7F2) (CBMAB-C8694-LY)

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Target: CAPN5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 7F2
Application*: IH
Mouse Anti-CAPN5 Recombinant Antibody (7F2)
Datasheet SDS

Mouse Anti-CAPN5 Recombinant Antibody (3C10) (CBMAB-C5774-LY)

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Target: CAPN5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C10
Application*: E, WB
Mouse Anti-CAPN5 Recombinant Antibody (3C10)
Datasheet SDS

Human CAPN5 ELISA Kit (V2LY-0626-LY5544)

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Target: CAPN5
Sensitivity: 0.0091 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Human CAPN5 ELISA Kit
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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