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CCM2

CCM2 (CCM2 Scaffolding Protein) is a Protein Coding gene. Diseases associated with CCM2 include Cerebral Cavernous Malformations 2 and Cavernous Hemangioma. Among its related pathways are p38 MAPK signaling pathway (Pathway Interaction Database) and Regulation of p38-alpha and p38-beta. An important paralog of this gene is CCM2L.
Full Name
CCM2 Scaffolding Protein
Function
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity).
May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
Biological Process
Blood vessel endothelial cell differentiation Source: Ensembl
Cell-cell junction organization Source: Ensembl
Endothelial cell development Source: Ensembl
Endothelial tube morphogenesis Source: MGI
Inner ear development Source: Ensembl
Integrin-mediated signaling pathway Source: UniProtKB
In utero embryonic development Source: Ensembl
Multicellular organism growth Source: Ensembl
Pericardium development Source: Ensembl
Stress-activated MAPK cascade Source: UniProtKB
Vasculogenesis Source: UniProtKB
Venous blood vessel morphogenesis Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Cerebral cavernous malformations 2 (CCM2): A congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.

Anti-CCM2 antibodies

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Mouse Anti-CCM2 Recombinant Antibody (1B9) (CBMAB-C3686-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B9
Application*: IF, WB

Mouse Anti-CCM2 Recombinant Antibody (1D1) (CBMAB-C3793-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D1
Application*: WB

Mouse Anti-CCM2 Recombinant Antibody (1E9) (CBMAB-C3990-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E9
Application*: P, WB

Mouse Anti-CCM2 Recombinant Antibody (2 E4) (CBMAB-C4319-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2 E4
Application*: IF, C, WB

Mouse Anti-CCM2 Recombinant Antibody (2C10) (CBMAB-C4746-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C10
Application*: IF, WB

Mouse Anti-CCM2 Recombinant Antibody (2E4) (CBMAB-C4996-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E4
Application*: WB, P, IC/IF

Mouse Anti-CCM2 Recombinant Antibody (2F9) (CBMAB-C5128-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F9
Application*: IF, P, WB

Mouse Anti-CCM2 Recombinant Antibody (3B7) (CBMAB-C5746-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B7
Application*: IF, WB

Mouse Anti-CCM2 Recombinant Antibody (5H4) (CBMAB-C7724-LY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5H4
Application*: IF, WB

Mouse Anti-CCM2 Recombinant Antibody (CBYY-C1099) (CBMAB-C2536-YY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C1099
Application*: IF, WB

Mouse Anti-CCM2 Recombinant Antibody (CBFYC-1006) (CBMAB-C1063-FY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1006
Application*: WB, IH, P

Mouse Anti-CCM2 Recombinant Antibody (CBFYC-1007) (CBMAB-C1064-FY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-1007
Application*: WB

Mouse Anti-CCM2 Recombinant Antibody (CBFYC-1008) (CBMAB-C1065-FY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1008
Application*: WB, P, IF

Mouse Anti-CCM2 Recombinant Antibody (CBFYC-1009) (CBMAB-C1066-FY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1009
Application*: IF, WB

Mouse Anti-CCM2 Recombinant Antibody (CBFYC-1010) (CBMAB-C1067-FY)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1010
Application*: IF, IH, WB

Mouse Anti-CCM2 Recombinant Antibody (CBXC-2827) (CBMAB-C5690-CQ)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2827
Application*: WB, IF

Mouse Anti-CCM2 Recombinant Antibody (CBXC-2759) (CBMAB-C5692-CQ)

Datasheet SDS
Target: CCM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2759
Application*: WB, IH, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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