CCNE1

Cyclin E1 is a key cell cycle regulator in normal cells. Many studies have found Cyclin E1 to be linked to disease progression and patient prognoses in several cancers including breast, bladder, colon, and ovarian carcinomas. Cyclin E1 is commonly uncontrolled in various cancers, and current research has found Cyclin E1 overexpression to be the cause for resistance against trastuzumab in HER2(+) breast cancer patients.
Full Name
Cyclin E1
Function
Essential for the control of the cell cycle at the G1/S (start) transition.
Biological Process
Cell division Source: UniProtKB-KW
DNA replication initiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: BHF-UCL
Homologous chromosome pairing at meiosis Source: Ensembl
Mitotic cell cycle phase transition Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of mesenchymal stem cell proliferation Source: BHF-UCL
Protein phosphorylation Source: MGI
Regulation of cellular protein localization Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Telomere maintenance Source: Ensembl
Wnt signaling pathway Source: Ensembl
Cellular Location
Nucleus
PTM
Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
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Anti-CCNE1 antibodies

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Mouse Anti-CCNE1 Recombinant Antibody (HE111) (CBMAB-C9911-LY)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Mouse, Rat, Human
Clone: HE111
Application*: WB, IP, IF, P
Datasheet SDS

Rabbit Anti-CCNE1 Recombinant Antibody (C1467) (CBMAB-C1467-CN)

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Target: CCNE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C1467
Application*: WB, IF
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1047) (CBMAB-C1104-FY)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1047
Application*: IH
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1046) (CBMAB-C1103-FY)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1046
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1045) (CBMAB-C1102-FY)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-1045
Application*: IF, P, WB, IP
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1044) (CBMAB-C1101-FY)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1044
Application*: P
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (03) (CBMAB-C1698-LY)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 03
Application*: IC/IF
Datasheet SDS

Rabbit Anti-CCNE1 Recombinant Antibody (
3A5) (V2LY-0725-LY1548)

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Target: CCNE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3A5
Application*: E, IH, IF
Datasheet SDS

Rabbit Anti-CCNE1 Recombinant Antibody (
9H12) (V2LY-0725-LY1039)

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Target: CCNE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 9H12
Application*: E, IF
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (CBT3371) (V2LY-0625-LY1460)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3371
Application*: IH, F
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (CBT2334) (V2LY-0625-LY1459)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2334
Application*: IH, F
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (CBT4283) (V2LY-0625-LY140)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4283
Application*: IH, F
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (CBT4072) (V2LY-0625-LY131)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT4072
Application*: F
Datasheet SDS

CCNE1 Matched Antibody Pair (200) (APMAB-200LY)

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Target: CCNE1
Specificity: Human
Datasheet SDS

Mouse Anti-CCNE1 Recombinant Antibody (HE12) (CBMAB-1327-CN)

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Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: HE12
Application*: IF, P, WB, IP
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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