Sign in or Register   Sign in or Register
  |  

CCNE1

Cyclin E1 is a key cell cycle regulator in normal cells. Many studies have found Cyclin E1 to be linked to disease progression and patient prognoses in several cancers including breast, bladder, colon, and ovarian carcinomas. Cyclin E1 is commonly uncontrolled in various cancers, and current research has found Cyclin E1 overexpression to be the cause for resistance against trastuzumab in HER2(+) breast cancer patients.
Full Name
Cyclin E1
Function
Essential for the control of the cell cycle at the G1/S (start) transition.
Biological Process
Cell division Source: UniProtKB-KW
DNA replication initiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: BHF-UCL
Homologous chromosome pairing at meiosis Source: Ensembl
Mitotic cell cycle phase transition Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of mesenchymal stem cell proliferation Source: BHF-UCL
Protein phosphorylation Source: MGI
Regulation of cellular protein localization Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Telomere maintenance Source: Ensembl
Wnt signaling pathway Source: Ensembl
Cellular Location
Nucleus
PTM
Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.

Anti-CCNE1 antibodies

Loading...

Mouse Anti-CCNE1 Recombinant Antibody (CBXC-2950) (CBMAB-C4707-CQ)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXC-2950
Application*: WB, F, E

Mouse Anti-CCNE1 Recombinant Antibody (CBXC-1301) (CBMAB-C4706-CQ)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1301
Application*: IH

Mouse Anti-CCNE1 Recombinant Antibody (CBXC-0150) (CBMAB-C4705-CQ)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-0150
Application*: IP, WB

Mouse Anti-CCNE1 Recombinant Antibody (CBXC-0149) (CBMAB-C4704-CQ)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0149
Application*: F, IH, IP, WB

Mouse Anti-CCNE1 Recombinant Antibody (CBXC-0152) (CBMAB-C4703-CQ)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0152
Application*: F, IF, IH, WB

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1048) (CBMAB-C1105-FY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1048
Application*: DB, WB

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1047) (CBMAB-C1104-FY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Specificity: Human
Clone: CBFYC-1047
Application*: IC, IF

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1046) (CBMAB-C1103-FY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-1046
Application*: P, C

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1045) (CBMAB-C1102-FY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBFYC-1045
Application*: IP, WB

Mouse Anti-CCNE1 Recombinant Antibody (CBFYC-1044) (CBMAB-C1101-FY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1044
Application*: P

Rabbit Anti-CCNE1 Recombinant Antibody (EG518) (CBMAB-EN590-LY)

Datasheet SDS
Target: CCNE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG518
Application*: IHC: 1:50~1:100

Mouse Anti-CCNE1 Recombinant Antibody (IHC553) (CBMAB-MA031-YC)

Datasheet SDS
Target: CCNE1
Host: Mouse
Specificity: Human
Clone: IHC553
Application*: IH

Mouse Anti-CCNE1 Recombinant Antibody (HE111) (CBMAB-C9911-LY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: HE111
Application*: WB, IP, IF

Rabbit Anti-CCNE1 Recombinant Antibody (SP146) (CBMAB-C1467-CN)

Datasheet SDS
Target: CCNE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP146
Application*: P

Mouse Anti-CCNE1 Recombinant Antibody (HE172) (CBMAB-C1466-CN)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: HE172
Application*: IF, IP

Rabbit Anti-CCNE1 Recombinant Antibody (D7T3U) (CBMAB-C1465-CN)

Datasheet SDS
Target: CCNE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D7T3U
Application*: WB

Rabbit Anti-CCNE1 Recombinant Antibody (9H224) (CBMAB-C1464-CN)

Datasheet SDS
Target: CCNE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 9H224
Application*: FC, IF, IP, WB

Mouse Anti-CCNE1 Recombinant Antibody (8D113) (CBMAB-C1463-CN)

Datasheet SDS
Target: CCNE1
Host: Mouse
Specificity: Human
Clone: 8D113
Application*: WB

Mouse Anti-CCNE1 Recombinant Antibody (3G117) (CBMAB-C6112-LY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G117
Application*: F, IH, IP, WB

Mouse Anti-CCNE1 Recombinant Antibody (03) (CBMAB-C1698-LY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 03
Application*: IC/IF, IF

Mouse Anti-CCNE1 Recombinant Antibody (0.T.206) (CBMAB-C1434-LY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 0.T.206
Application*: E

Mouse Anti-CCNE1 Recombinant Antibody (2121C1a) (CBMAB-C0606-LY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2121C1a
Application*: DB, WB

Mouse Anti-CCNE1 Recombinant Antibody (0.N.244) (CBMAB-C0012-LY)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 0.N.244
Application*: F, IF, C, WB

Mouse Anti-CCNE1 Recombinant Antibody (CBLNC-151) (CBMAB-1329-CN)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLNC-151
Application*: IH

Mouse Anti-CCNE1 Recombinant Antibody (5F8C5) (CBMAB-1328-CN)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 5F8C5
Application*: WB, E, F

Mouse Anti-CCNE1 Recombinant Antibody (HE12) (CBMAB-1327-CN)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: HE12
Application*: IH, P, WB

Mouse Anti-CCNE1 Recombinant Antibody (168) (CBMAB-1326-CN)

Datasheet SDS
Target: CCNE1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 168
Application*: WB, IP

CCNE1 Matched Antibody Pair (200) (APMAB-200LY)

Datasheet SDS
Target: CCNE1
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare