CD27

CD27 (CD27 Molecule) is a Protein Coding gene. Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Disease. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process.

CD27 Molecule

CD27 Molecule

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Cell surface receptor signaling pathway Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: BHF-UCL
Immunoglobulin mediated immune response Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of T cell apoptotic process Source: Ensembl
Positive regulation of B cell differentiation Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
Positive regulation of T cell differentiation Source: InterPro
Response to ethanol Source: Ensembl
Tumor necrosis factor-mediated signaling pathway Source: Reactome

Membrane

Lymphoproliferative syndrome 2 (LPFS2): An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.

Extracellular: 20-191
Helical: 192-212
Cytoplasmic: 213-260

Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.