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CD27

CD27 (CD27 Molecule) is a Protein Coding gene. Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Disease. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process.
Full Name
CD27 Molecule
Function
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Biological Process
Cell surface receptor signaling pathway Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: BHF-UCL
Immunoglobulin mediated immune response Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of T cell apoptotic process Source: Ensembl
Positive regulation of B cell differentiation Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
Positive regulation of T cell differentiation Source: InterPro
Response to ethanol Source: Ensembl
Tumor necrosis factor-mediated signaling pathway Source: Reactome
Cellular Location
Membrane
Involvement in disease
Lymphoproliferative syndrome 2 (LPFS2): An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Topology
Extracellular: 20-191
Helical: 192-212
Cytoplasmic: 213-260
PTM
Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.

Anti-CD27 antibodies

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Rat Anti-Cd27 Recombinant Antibody (CBYJT-3861) (CBMAB-T3256-YJ)

Datasheet SDS
Target: Cd27
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3861
Application*: WB

Mouse Anti-CD27 Recombinant Antibody (CBYJT-1090) (CBMAB-T0100-YJ)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1090
Application*: WB, F, N

Mouse Anti-CD27 Recombinant Antibody (CBYJT-1089) (CBMAB-T0099-YJ)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1089
Application*: F, N, WB

Mouse Anti-CD27 Recombinant Antibody (O323) (CBMAB-C0963-CQ)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: O323
Application*: F

Mouse Anti-CD27 Recombinant Antibody (LT27) (CBMAB-C0834-CQ)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: LT27
Application*: F

Mouse Anti-CD27 Recombinant Antibody (LPFS2/1611) (CBMAB-C0829-CQ)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LPFS2/1611
Application*: F, IF, P

Armenian Hamster Anti-CD27 Recombinant Antibody (LG.7F9) (CBMAB-C0809-CQ)

Datasheet SDS
Target: CD27
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: LG.7F9
Application*: F, IP, FN

Mouse Anti-CD27 Recombinant Antibody (CBFYC-1188) (CBMAB-C1246-FY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBFYC-1188
Application*: F, IC, C

Mouse Anti-CD27 Recombinant Antibody (CBFYC-1187) (CBMAB-C1245-FY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1187
Application*: E

Rabbit Anti-CD27 Recombinant Antibody (CBFYC-1186) (CBMAB-C1244-FY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1186
Application*: E

Rabbit Anti-CD27 Recombinant Antibody (CBFYC-1185) (CBMAB-C1243-FY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1185
Application*: E, WB

Hamster Anti-CD27 Recombinant Antibody (LG.8A6) (CBMAB-C3424-CQ)

Datasheet SDS
Target: CD27
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: LG.8A6
Application*: E, F, IP

Rat Anti-CD27 Recombinant Antibody (CBXC-1405) (CBMAB-C3422-CQ)

Datasheet SDS
Target: CD27
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1405
Application*: F

Hamster Anti-CD27 Recombinant Antibody (LG.3A10) (CBMAB-C1781-CQ)

Datasheet SDS
Target: CD27
Host: Hamster
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: LG.3A10
Application*: F

Rat Anti-CD27 Recombinant Antibody (10M2) (CBMAB-C2409-LY)

Datasheet SDS
Target: CD27
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 10M2
Application*: F

Rabbit Anti-CD27 Recombinant Antibody (034) (CBMAB-C1719-LY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 034
Application*: E

Rat Anti-CD27 Recombinant Antibody (137915) (CBMAB-C0305-LY)

Datasheet SDS
Target: CD27
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 137915
Application*: F, IC, MC, EC

Rat Anti-CD27 Recombinant Antibody (137910) (CBMAB-C0304-LY)

Datasheet SDS
Target: CD27
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 137910
Application*: WB, IC

Rabbit Anti-CD27 Recombinant Antibody (012) (CBMAB-C0043-LY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 012
Application*: F, IC/IF, IF

Mouse Anti-CD27 Recombinant Antibody (58) (CBMAB-AP1015LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 58
Application*: ELISA, IHC, WB

Mouse Anti-CD27 Recombinant Antibody (DEN-3) (CBMAB-AP1014LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DEN-3
Application*: FC

Rabbit Anti-CD27 Recombinant Antibody (036) (CBMAB-C1725-LY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 036
Application*: E

Mouse Anti-CD27 Recombinant Antibody (137B4) (CBMAB-C2731-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 137B4
Application*: P, C, F

Rat Anti-CD27 Recombinant Antibody (CBFYC-1183) (CBMAB-C1241-FY)

Datasheet SDS
Target: CD27
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-1183
Application*: F

Mouse Anti-CD27 Recombinant Antibody (203-6) (CBMAB-C4344-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 203-6
Application*: F, IC, C

Mouse Anti-CD27 Recombinant Antibody (57703) (CBMAB-C7223-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 57703
Application*: WB, F, N, MC

Mouse Anti-CD27 Recombinant Antibody (7H21) (CBMAB-C8821-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H21
Application*: F, N, WB

Mouse Anti-CD27 Recombinant Antibody (CBFYC-1181) (CBMAB-C1239-FY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-1181
Application*: E, WB

Mouse Anti-CD27 Recombinant Antibody (CBYY-C0643) (CBMAB-C1933-YY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0643
Application*: F

Mouse Anti-CD27 Recombinant Antibody (CBFYC-0425) (CBMAB-C0470-FY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYC-0425
Application*: F, IF

Rat Anti-CD27 Recombinant Antibody (CBFYC-0269) (CBMAB-C0299-FY)

Datasheet SDS
Target: CD27
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0269
Application*: WB, IC

Rabbit Anti-CD27 Recombinant Antibody (CBFYC-0111) (CBMAB-C0128-FY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0111
Application*: F, IC, IF

Mouse Anti-CD27 Recombinant Antibody (CBFYC-0005) (CBMAB-C0011-FY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0005
Application*: F

Mouse Anti-CD27 Recombinant Antibody (1E2-A3) (CBMAB-A9337-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1E2-A3
Application*: WB, E

Rabbit Anti-CD27 Recombinant Antibody (023) (CBMAB-C0053-LY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 023
Application*: F

Mouse Anti-CD27 Recombinant Antibody (09) (CBMAB-C0099-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 09
Application*: F

Mouse Anti-CD27 Recombinant Antibody (203.6) (CBMAB-C0578-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 203.6
Application*: F, IF

Mouse Anti-CD27 Recombinant Antibody (3H1174) (CBMAB-C1156-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H1174
Application*: F

Mouse Anti-CD27 Recombinant Antibody (1C6D1) (CBMAB-C3762-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C6D1
Application*: E

Mouse Anti-CD27 Recombinant Antibody (1E2-A3) (CBMAB-C3930-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1E2-A3
Application*: E, WB

Mouse Anti-CD27 Recombinant Antibody (CBYY-C0100) (CBMAB-C0437-YY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: CBYY-C0100
Application*: F

Rabbit Anti-CD27 Recombinant Antibody (CBYY-C1283) (CBMAB-C2721-YY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-C1283
Application*: E, WB

Mouse Anti-CD27 Recombinant Antibody (CBYY-C1284) (CBMAB-C2722-YY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1284
Application*: F, N, WB

Rat Anti-CD27 Recombinant Antibody (CBYY-C1285) (CBMAB-C2723-YY)

Datasheet SDS
Target: CD27
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C1285
Application*: E

Mouse Anti-CD27 Recombinant Antibody (CBYY-C1286) (CBMAB-C2724-YY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1286
Application*: F

Mouse Anti-CD27 Recombinant Antibody (7H206) (CBMAB-C0395-CN)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H206
Application*: E, FC

Mouse Anti-CD27 Recombinant Antibody (6D259) (CBMAB-C1634-CN)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 6D259
Application*: FC, IF, IH

Mouse Anti-CD27 Recombinant Antibody (CLB-27) (CBMAB-C1635-CN)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CLB-27
Application*: IF

Mouse Anti-CD27 Recombinant Antibody (B30C7) (CBMAB-C10132-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: B30C7
Application*: F

Hamster Anti-CD27 Recombinant Antibody (LG.3810) (CBMAB-C10137-LY)

Datasheet SDS
Target: CD27
Host: Hamster
Antibody Isotype: IgG1
Specificity: Mouse
Clone: LG.3810
Application*: IH

Rat Anti-CD27 Recombinant Antibody (RM0342-10M2) (CBMAB-C10136-LY)

Datasheet SDS
Target: CD27
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0342-10M2
Application*: F

Mouse Anti-CD27 Recombinant Antibody (MM0165-7H21) (CBMAB-C10140-LY)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0165-7H21
Application*: WB, N, F

Rabbit Anti-CD27 Recombinant Antibody (CBR083G) (CBMAB-BT014LY)

Datasheet SDS
Target: CD27
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR083G
Application*: WB, IP, IHC, ICC

Mouse Anti-CD27 Recombinant Antibody (CBXC-2713) (CBMAB-C0085-CQ)

Datasheet SDS
Target: CD27
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXC-2713
Application*: F, IH, IF, C

CD27 Matched Antibody Pair (213) (APMAB-213LY)

Datasheet SDS
Target: CD27
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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