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CNOT4

CNOT4 (CCR4-NOT Transcription Complex Subunit 4) is a Protein Coding gene. Diseases associated with CNOT4 include Adenoiditis. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
Full Name
CCR4-NOT Transcription Complex Subunit 4
Function
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292).

Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038).

Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).

Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391).

As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391).
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
Protein autoubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of megakaryocyte differentiation Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
PTM
Autoubiquitinated.

Anti-CNOT4 antibodies

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Mouse Anti-CNOT4 Recombinant Antibody (CBWJC-2867) (CBMAB-C3993WJ)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2867
Application*: IH

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2702) (CBMAB-C3771-CQ)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2702
Application*: WB, IH

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2174) (CBMAB-C3768-CQ)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2174
Application*: WB, F

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2226) (CBMAB-C3767-CQ)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2226
Application*: WB

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2796) (CBMAB-C2335-CQ)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-2796
Application*: E, WB

Mouse Anti-CNOT4 (AA 190-455) Recombinant Antibody (CBFYC-1997) (CBMAB-C2063-FY)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1997
Application*: P, WB

Mouse Anti-CNOT4 Recombinant Antibody (CBFYC-1996) (CBMAB-C2062-FY)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1996
Application*: WB

Rabbit Anti-CNOT4 Recombinant Antibody (EG750) (CBMAB-EN905-LY)

Datasheet SDS
Target: CNOT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG750
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Mouse Anti-CNOT4 Recombinant Antibody (CBCNC-229) (CBMAB-C2526-CN)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNC-229
Application*: E, WB

Mouse Anti-CNOT4 Recombinant Antibody (2A5) (CBMAB-C4622-LY)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A5
Application*: WB

Mouse Anti-CNOT4 Recombinant Antibody (1H2) (CBMAB-C4231-LY)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1H2
Application*: WB, IH, P

Mouse Anti-CNOT4 Recombinant Antibody (1F9) (CBMAB-C4099-LY)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F9
Application*: WB

Mouse Anti-CNOT4 Recombinant Antibody (1F10) (CBMAB-C4012-LY)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F10
Application*: P, WB

Mouse Anti-CNOT4 Recombinant Antibody (343CT14.6.5) (CBMAB-C1002-LY)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 343CT14.6.5
Application*: E, WB

Mouse Anti-CNOT4 Recombinant Antibody (3D11) (CBMAB-1399-CN)

Datasheet SDS
Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 3D11
Application*: WB, F
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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