CNOT4

CNOT4 (CCR4-NOT Transcription Complex Subunit 4) is a Protein Coding gene. Diseases associated with CNOT4 include Adenoiditis. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
Full Name
CCR4-NOT Transcription Complex Subunit 4
Function
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292).

Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038).

Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).

Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391).

As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391).
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
Protein autoubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of megakaryocyte differentiation Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
PTM
Autoubiquitinated.
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Anti-CNOT4 antibodies

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Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2226) (CBMAB-C3767-CQ)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-2226
Application*: WB
Datasheet SDS

Mouse Anti-CNOT4 Recombinant Antibody (1F9) (CBMAB-C4099-LY)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1F9
Application*: WB
Datasheet SDS

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2174) (V2LY-1206-LY471)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-2174
Application*: WB
Datasheet SDS

Mouse Anti-CNOT4 Recombinant Antibody (CBXC-2796) (V2LY-1206-LY469)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-2796
Application*: WB
Datasheet SDS

Mouse Anti-CNOT4 Recombinant Antibody (CBFYC-1997) (V2LY-1206-LY468)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1997
Application*: E, WB
Datasheet SDS

Mouse Anti-CNOT4 Recombinant Antibody (2A5) (V2LY-1206-LY467)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2A5
Application*: WB
Datasheet SDS

Mouse Anti-CNOT4 Recombinant Antibody (1H2) (V2LY-1206-LY466)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1H2
Application*: WB, IH
Datasheet SDS

Mouse Anti-CNOT4 Recombinant Antibody (1F10) (V2LY-1206-LY464)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1F10
Application*: P
Datasheet SDS

Mouse Anti-CNOT4 Recombinant Antibody (C1002) (V2LY-1206-LY463)

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Target: CNOT4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: C1002
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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