DIEXF

DIEXF (Digestive Organ Expansion Factor Homolog (Zebrafish)) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include U3 snoRNA binding.

Full Name

digestive organ expansion factor homolog (zebrafish)

Function

Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity).

Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:25007945, PubMed:27657329, PubMed:23357851).

Also involved in the sympathetic neuronal development (By similarity).

Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329).

Biological Process

Embryonic organ development Source: UniProtKB
Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Positive regulation of embryonic development Source: UniProtKB
Protein catabolic process Source: UniProtKB
Protein destabilization Source: UniProtKB
Protein localization to nucleolus Source: UniProtKB

Cellular Location

Nucleolus

PTM

Phosphorylated. Phosphorylation is required to promote p53/TP53 degradation in the nucleolus which promotes cell cycle progression and liver development.