DISP1

The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo.

Full Name

dispatched RND transporter family member 1

Function

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity).

Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404).

Biological Process

Diaphragm development Source: UniProtKB
Peptide transport Source: UniProtKB
Protein homotrimerization Source: UniProtKB
Regulation of protein secretion Source: UniProtKB

Cellular Location

Membrane