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EBF1

EBF1 (Early B-Cell Factor 1) is a Protein Coding gene. Diseases associated with EBF1 include fetal erythroblastosis and hematologic cancer. Among its related pathways are Developmental Biology and Adipogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and C2H2 zinc finger domain binding. An important paralog of this gene is EBF2.
Full Name
EBF1
Research Area
Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034).

Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity).

(Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461).

In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314).
Biological Process
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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Anti-EBF1 antibodies

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Mouse Anti-EBF1 Antibody (1B1) (CBMAB-0329-YC)

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Target: EBF1
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1B1
Application*: IP
Datasheet SDS

Mouse Anti-EBF1 Recombinant Antibody (1G8) (V2LY-0425-LY1277)

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Target: EBF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G8
Application*: WB, E
Datasheet SDS

Mouse Anti-EBF1 Recombinant Antibody (E0703) (V2LY-0425-LY1276)

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Target: EBF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: E0703
Application*: WB, E
Datasheet SDS

Mouse Anti-EBF1 Monoclonal Antibody (1B1) (V2LY-0425-LY1275)

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Target: EBF1
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human, Mouse, Rat
Clone: 1B1
Application*: IP
Datasheet SDS

Mouse Anti-EBF1 Recombinant Antibody (1G8) (CBMAB-A2424-LY)

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Target: EBF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G8
Application*: WB, E
Datasheet SDS

Mouse Anti-EBF1 Recombinant Antibody (T26-818) (CBMAB-E0703-FY)

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Target: EBF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: T26-818
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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