FCGR1

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.

Full Name

FC RECEPTOR, IGG, HIGH AFFINITY

Research Area

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Innate immune response Source: UniProtKB-KW
Phagocytosis, engulfment Source: ProtInc
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Regulation of immune response Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Cell membrane. Stabilized at the cell membrane through interaction with FCER1G.

Topology

Extracellular: 16-292
Helical: 293-313
Cytoplasmic: 314-374

PTM

Phosphorylated on serine residues.

Anti-FCGR1 antibodies

Rat Anti-FCGR1 Recombinant Antibody (CBFYC-2667) (CBMAB-C2741-FY)

Datasheet

SDS

Target: FCGR1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYC-2667

Application*: F

Rabbit Anti-FCGR1 Recombinant Antibody (CBFYC-2666) (CBMAB-C2740-FY)

Datasheet

SDS

Target: FCGR1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-2666

Application*: E, P

Rabbit Anti-FCGR1 Recombinant Antibody (CBFYC-0491) (CBMAB-C0541-FY)

Datasheet

SDS

Target: FCGR1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-0491

Application*: F

Rabbit Anti-FCGR1 Recombinant Antibody (CBFYC-0119) (CBMAB-C0136-FY)

Datasheet

SDS

Target: FCGR1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-0119

Application*: F, IC, IF

Rat Anti-FCGR1 Recombinant Antibody (CBXF-2553) (CBMAB-F3006-CQ)

Datasheet

SDS

Target: FCGR1

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXF-2553

Application*: WB

Rat Anti-FCGR1 Recombinant Antibody (CBXF-2552) (CBMAB-F0015-CQ)

Datasheet

SDS

Target: FCGR1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXF-2552

Application*: F, MC

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)