FCGR1

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.

Full Name

FC RECEPTOR, IGG, HIGH AFFINITY

Research Area

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Innate immune response Source: UniProtKB-KW
Phagocytosis, engulfment Source: ProtInc
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Regulation of immune response Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Cell membrane. Stabilized at the cell membrane through interaction with FCER1G.

Topology

Extracellular: 16-292
Helical: 293-313
Cytoplasmic: 314-374

PTM

Phosphorylated on serine residues.