GPBAR1

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.

Full Name

G protein-coupled bile acid receptor 1

Function

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

Biological Process

Cell surface bile acid receptor signaling pathway Source: UniProtKB
Cellular response to bile acid Source: UniProtKB
Positive regulation of cholangiocyte proliferation Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Regulation of bicellular tight junction assembly Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-50
Helical: 51-71
Extracellular: 72-85
Helical: 86-106
Cytoplasmic: 107-125
Helical: 126-146
Extracellular: 147-165
Helical: 166-186
Cytoplasmic: 187-228
Helical: 229-249
Extracellular: 250-261
Helical: 262-282
Cytoplasmic: 283-330