GPX3

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Full Name
GLUTATHIONE PEROXIDASE 3
Function
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Biological Process
Hydrogen peroxide catabolic process Source: GO_Central
Response to lipid hydroperoxide Source: UniProtKB
Cellular Location
Secreted
PTM
The N-terminus is blocked.
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Anti-GPX3 antibodies

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Mouse Anti-GPX3 Recombinant Antibody (23B1) (CBMAB-G4740-LY)

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Target: GPX3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 23B1
Application*: WB
Datasheet SDS

Mouse Anti-GPX3 Recombinant Antibody (CBLG1-1680) (CBMAB-G4746-LY)

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Target: GPX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1680
Application*: WB
Datasheet SDS

Mouse Anti-GPX3 Recombinant Antibody (CBLG1-1679) (CBMAB-G4745-LY)

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Target: GPX3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1679
Application*: E, IP
Datasheet SDS

Mouse Anti-GPX3 Recombinant Antibody (CBLG1-1676) (CBMAB-G4742-LY)

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Target: GPX3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1676
Application*: E, IP
Datasheet SDS

Mouse Anti-GPX3 Recombinant Antibody (55A) (CBMAB-G4741-LY)

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Target: GPX3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 55A
Application*: IP, E
Datasheet SDS

Mouse Anti-GPX3 Recombinant Antibody (CBFYH-0468) (CBMAB-H1339-FY)

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Target: GPX3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0468
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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