GRIK4

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

glutamate ionotropic receptor kainate type subunit 4

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Chemical synaptic transmission Source: ProtInc
Glutamate receptor signaling pathway Source: ProtInc
Modulation of chemical synaptic transmission Source: GO_Central
Synaptic transmission, glutamatergic Source: GO_Central

Cell membrane; Postsynaptic cell membrane

Extracellular: 21-545
Helical: 546-566
Cytoplasmic: 567-623
Helical: 624-644
Extracellular: 645-804
Helical: 805-825
Cytoplasmic: 826-956