Mouse Anti-GRIK4 Recombinant Antibody (CBT2011) (V2LY-0625-LY740)

Name: Mouse Anti-GRIK4 Recombinant Antibody (CBT2011)
SKU: V2LY-0625-LY740
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2011

Antibody Isotype

IgG2b

Application

IHC, ICC, FC

Basic Information

Immunogen

Purified recombinant fragment of human GRIK4 (AA: extra 21-166) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

glutamate ionotropic receptor kainate type subunit 4

Entrez Gene ID

2900

UniProt ID

Q16099

Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Biological Process

Chemical synaptic transmission Source: ProtInc
Glutamate receptor signaling pathway Source: ProtInc
Modulation of chemical synaptic transmission Source: GO_Central
Synaptic transmission, glutamatergic Source: GO_Central

Cellular Location

Cell membrane; Postsynaptic cell membrane

Topology

Extracellular: 21-545
Helical: 546-566
Cytoplasmic: 567-623
Helical: 624-644
Extracellular: 645-804
Helical: 805-825
Cytoplasmic: 826-956

More Infomation

References

Negrete‐Díaz, J. V., Falcón‐Moya, R., & Rodríguez‐Moreno, A. (2022). Kainate receptors: from synaptic activity to disease. The FEBS Journal, 289(17), 5074-5088.

Sun, Q., Yuan, F., Yuan, R., Ren, D., Zhu, Y., Bi, Y., ... & He, G. (2019). GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity. Medicine, 98(19).

Arora, V., Pecoraro, V., Aller, M. I., Román, C., Paternain, A. V., & Lerma, J. (2018). Increased Grik4 gene dosage causes imbalanced circuit output and human disease-related behaviors. Cell reports, 23(13), 3827-3838.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-GRIK4 Recombinant Antibody (CBT4460)

Rabbit Anti-GRIK4 Recombinant Antibody (CBLY1-029)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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