Rabbit Anti-GRIK4 Recombinant Antibody (CBLY1-029) (CBMAB-K0350-LY)

This product is antibody recognizes GRIK4. The antibody CBLY1-029 immunoassay techniques such as: WB.
See all GRIK4 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Mouse, Rat, Human

Clone

CBLY1-029

Antibody Isotype

IgG

Application

Basic Information

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

glutamate ionotropic receptor kainate type subunit 4

Introduction

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	2900
Mouse	110637
Rat	24406

UniProt ID

Human	Q16099
Mouse	Q8BMF5
Rat	Q01812

Alternative Names

KA1; EAA1; GRIK; GluK4

Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Biological Process

Chemical synaptic transmission Source: ProtInc
Glutamate receptor signaling pathway Source: ProtInc
Modulation of chemical synaptic transmission Source: GO_Central
Synaptic transmission, glutamatergic Source: GO_Central

Cellular Location

Cell membrane; Postsynaptic cell membrane

Topology

Extracellular: 21-545
Helical: 546-566
Cytoplasmic: 567-623
Helical: 624-644
Extracellular: 645-804
Helical: 805-825
Cytoplasmic: 826-956

References

Negrete‐Díaz, J. V., Falcón‐Moya, R., & Rodríguez‐Moreno, A. (2022). Kainate receptors: from synaptic activity to disease. The FEBS Journal, 289(17), 5074-5088.

Sun, Q., Yuan, F., Yuan, R., Ren, D., Zhu, Y., Bi, Y., ... & He, G. (2019). GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity. Medicine, 98(19).

Arora, V., Pecoraro, V., Aller, M. I., Román, C., Paternain, A. V., & Lerma, J. (2018). Increased Grik4 gene dosage causes imbalanced circuit output and human disease-related behaviors. Cell reports, 23(13), 3827-3838.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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